High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies
MUSCLE & NERVE
2006; 33 (3): 433-435
We describe a 48-year-old woman with seronegative myasthenia gravis (MG) and high-titer of anti-MuSK antibody. She had severe bulbar and respiratory weakness with minimal limb weakness for 2 years. Her disease responded poorly to all the conventional immunosuppressive regimens. Treatment with immunoablative dose of cyclophosphamide led to dramatic and sustained remission of her symptoms. High-dose cyclophosphamide is an effective alternative in patients with unusually refractory disease.
View details for DOI 10.1002/mus.20411
View details for PubMedID 16116645