School of Medicine
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Associate Professor (Research) of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly Interests In the coming years, I plan to further determine the genetic and immunological basis of diseases with autoimmunity or immune dysregulation in children. I believe that much can still be learned from the in depth mechanistic studies of pediatric autoimmune diseases. Genomic analysis of the patients' samples has become possible which may provide a rapid indication of altered target molecules. I plan to implement robust functional studies to define the consequences of these genetic abnormalities and bridge them to the patient's clinical phenotype.
Understanding functional consequences of gene mutations in single case/family first and then validating the molecular and cellular defects in other patients with similar phenotypes, will anticipate and complement cellular and gene therapy strategies.
For further information please visit the Bacchetta Lab website:
Laura K. Bachrach
Professor of Pediatrics (Endocrinology) at the Lucile Salter Packard Children's Hospital, Emerita
Current Research and Scholarly Interests Prevention of osteoporosis begins in childhood and adolescence by measures that maximize acquistion of bone mineral during the critical adolescent years. Body mass, calcium nutriture, physical activity, growth and sex steroid hormones, and genetic factors are all thought to be important determinants of bone mass although the relative contribution of each remains controversial.
Professor of Genetics
Current Research and Scholarly Interests We examine how cells communicate and function during fetal development. The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. In recent years we have focused on the vastly understudied biology of the trophoblast lineage, particularly how this lineage evolved.
Karthik Balakrishnan, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly Interests Dr. Balakrishnan's research focuses on innovative ways to improve and standardize treatments and measure outcomes in complex pediatric airway and aerodigestive conditions , as well as ways to reduce treatment costs and medical errors. By improving outcomes and reducing costs, he aims to improve the value of care, while also optimizing patient and caregiver experience during the care process.
Associate Professor of Genetics
Current Research and Scholarly Interests Our lab studies how intricate control of gene expression and cell signaling is regulated on a minute-by-minute basis to give rise to the remarkable diversity of cell types and tissue morphology that form the living blueprints of developing organisms. Work in the Barna lab is presently split into two main research efforts. The first is investigating ribosome-mediated control of gene expression genome-wide in space and time during cellular differentiation and organismal development. This research is opening a new field of study in which we apply sophisticated mass spectrometry, computational biology, genomics, and developmental genetics, to characterize a ribosome code to gene expression. Our research has shown that not all of the millions of ribosomes within a cell are the same and that ribosome heterogeneity can diversify how genomes are translated into proteomes. In particular, we seek to address whether fundamental aspects of gene regulation are controlled by ribosomes harboring a unique activity or composition that are tuned to translating specific transcripts by virtue of RNA regulatory elements embedded within their 5’UTRs. The second research effort is centered on employing state-of-the-art live cell imaging to visualize cell signaling and cellular control of organogenesis. This research has led to the realization of a novel means of cell-cell communication dependent on a dense network of actin-based cellular extension within developing organs that interconnect and facilitate the precise transmission of molecular information between cells. We apply and create bioengineering tools to manipulate such cellular interactions and signaling in-vivo.
Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly Interests Advanced imaging, including magnetic resonance imaging, of injury to the developing central nervous system; including fetal, neonatal, infant and young child; and, including nonaccidental injury (e.g. child abuse).
Professor (Teaching) of Pediatrics (General Pediatrics) and, by courtesy, at the Graduate School of Education
Bio Donald Barr is a Professor of Pediatrics in the Stanford School of Medicine, and Professor by Courtesy in the Graduate School of Education. He teaches in the Undergraduate Program in Human Biology, where he helped to found Human Biology's curriculum in health policy. His research has studied the effect of the organizational structure of the U.S. medical care delivery system on the quality of primary care. He has also studied cultural and linguistic barriers to health care access for low-income patients, and factors associated with higher rates of attrition from pre-medical studies among minority students at Stanford and other universities. The fourth edition of his book, Introduction to U.S. Health Policy: The Organization, Financing, and Delivery of Health Care in America, was published in 2016. The third edition of his book, Health Disparities in the United States: Social Class, Race, Ethnicity and the Social Determinants of Health, was published in 2019. In June 2003 Dr. Barr was awarded the Lloyd W. Dinkelspiel Award for Distinctive Contribution to Undergraduate Education at Stanford University. In 2006 he received the Miriam Aaron Roland Prize, which recognizes Stanford faculty who engage and involve students in integrating academic scholarship with significant and meaningful volunteer service to society.
Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly Interests Magnetic Resonance Imaging and Sonographic diagnosis of fetal anomalies.
Focus interest in the diagnosis and conservative (non-surgical and minimal radiation) management of congenital broncho pulmonary malformations.
Imaging of appendicitis in children.
Sonography of the pediatric testis.