School of Medicine
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Frank Lee and Carol Hall Professor, Senior Associate Vice Provost of Research and Professor of Genetics
Current Research and Scholarly Interests We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?
Marcia L. Stefanick, Ph.D.
Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests Marcia L. Stefanick, Ph.D is a Professor of Medicine Professor of Obstetrics and Gynecology, and by courtesy, Professor of Epidemiology and Population Health at Stanford University School of Medicine. Dr. Stefanick’s research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. She is currently the Principal Investigator the Women’s Health Initiative (WHI) Extension Study, having been the PI of the Stanford Clinical Center of the landmark WHI Clinical Trials and Observational Study since 1994 and Chair of the WHI Steering and Executive Committees from 1998-2011, as well as PI of the WHI Strong and Healthy (WHISH) Trial which is testing the hypothesis that a DHHS-based physical activity intervention, being delivered to a multi-ethnic cohort of about 24,000 WHI participants across the U.S., aged 68-99 when the trial started in 2015, will reduce major cardiovascular events over 8 years, compared to an equal number of “usual activity” controls. Dr. Stefanick is also PI of the Osteoporotic Study of Men (MrOS) which is continuing to conduct clinical assessments of bone and body composition in survivors of an original cohort of nearly 6000 men aged 65 and over in 2001. As founding Director of the Stanford Women’s Health and Sex Differences in Medicine (WHSDM, “wisdom”) Center, she plays a major role in promoting research and teaching on Sex and Gender in Human Physiology and Disease, Women’s Health and Queer Health and Medicine. Dr. Stefanick also plays major leadership roles at the Stanford School of Medicine, including as co-leader of the Population Sciences Program of the Stanford Cancer Institute, Stanford’s NCI-funded comprehensive cancer center.
Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology, with exercise physiology as a secondary focus. Her commitment to human research led to a post-doctoral fellowship in Cardiovascular Disease Prevention at the Stanford Prevention Research Center, which has been her academic home for nearly 40 years.
Assistant Professor of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly Interests Stoyanova lab develops new early cancer detection methods and therapeutic strategies for late stage cancers. The current research focus is on protein-based biomarkers for early cancer detection as well as development of new small molecule inhibitors and antibody-based therapies for prostate and other epithelial cancers. The ultimate goals of the laboratory are to improve the early diagnosis and prognosis of clinically significant cancers and guide the development of novel and effective therapeutic strategies for metastatic prostate and other epithelial cancers.
Aaron F. Straight
Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly Interests Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.
Professor of Urology, Emeritus
Current Research and Scholarly Interests We focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
John B. Sunwoo
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Dermatology
Current Research and Scholarly Interests My laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells; and (3) intra-tumor and inter-tumor heterogeneity.
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Bio Professor Swartz received his first lessons in resourcefulness and persistence growing up on a farm in South Dakota. After earning a BS in Chemical Engineering with Highest Honors from S. Dak. School of Mines and Technology, he began his professional career with Union Oil Co. of CA in Casper, Wyoming. Serving in the Drilling, Reservoir Engineering, and Production Departments provided an appreciation of the complexity and importance of large scale energy technologies. That experience also strengthened his belief that biological technologies offered the power and versatility to better address evolving societal needs. The MIT graduate programs in chemical engineering (MS) and biochemical engineering (Dsc) helped strengthen his biological training while broadening an appreciation for this emerging field. Following a 3 month exchange visit to the Soviet Union, he gained additional experience at Eli Lilly and participated in the development of the first recombinant DNA pharmaceutical to be approved, rDNA insulin. After two years, he moved to Genentech to help establish their drug production capability, developing the fermentation process for their first product, rDNA growth hormone.
After 17 years at Genentech in various line and project leadership positions, he joined the Stanford Chemical Engineering Department with a focus on an embryonic technology called cell-free protein synthesis (CFPS). Multiple technology breakthroughs from his lab motivated the founding of Sutro Biopharma which now has four promising anti-cancer drugs in clinical trials. A new company called Vaxcyte later spun out of Sutro to focus on complex human vaccines enabled by CFPS. Both companies are now publicly traded. Another company, GreenLight Biosciences, is focusing on inexpensive, large scale RNA production for use against agricultural pests. At Stanford, Professor Swartz is now focusing on expanding the basic capabilities of cell-free bioprocess while also developing technologies for targeted drug development, vaccines, circulating tumor cell assays, the carbon negative production of commodity biochemicals, and for economically attractive photosynthetic hydrogen production.
Susan M. Swetter, MD
Professor of Dermatology at Palo Alto Veterans Affairs Health Care System and the Stanford University Medical Center
Current Research and Scholarly Interests 1) Early detection of melanoma through enhanced screening, novel imaging technologies, and professional/public education to improve melanoma awareness. 2) Therapeutic prevention of melanoma and other skin cancers in high-risk groups. 4) Epidemiologic and sociodemographic melanoma risk factors. 4) Dermatologist liaison to ECOG-ACRIN Melanoma Committee and Co-founder/Co-Director of the national Melanoma Prevention Working Group, an interdisciplinary collaboration dedicated to melanoma control.
Professor of Surgery (Pediatric Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests One of the current primary interests of the lab is to investigate the mechanisms by which hepatocellular injury and recovery is influenced and controlled by hepatocyte metabolism.
A second focus of investigation is to identify molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include newborn sepsis and Necrotizing Enterocolitis (NEC).