Rapid volumetric gagCEST imaging of knee articular cartilage at 3 T: evaluation of improved dynamic range and an osteoarthritic population.
NMR in biomedicine
Chemical exchange saturation transfer of glycosaminoglycans, gagCEST, is a quantitative MR technique that has potential for assessing cartilage proteoglycan content at field strengths of 7 T and higher. However, its utility at 3 T remains unclear. The objective of this work was to implement a rapid volumetric gagCEST sequence with higher gagCEST asymmetry at 3 T to evaluate its sensitivity to osteoarthritic changes in knee articular cartilage and in comparison with T2 and T1ρ measures. We hypothesize that gagCEST asymmetry at 3 T decreases with increasing severity of osteoarthritis (OA). Forty-two human volunteers, including 10 healthy subjects and 32 subjects with medial OA, were included in the study. Knee Injury and Osteoarthritis Outcome Scores (KOOS) were assessed for all subjects, and Kellgren-Lawrence grading was performed for OA volunteers. Healthy subjects were scanned consecutively at 3 T to assess the repeatability of the volumetric gagCEST sequence at 3 T. For healthy and OA subjects, gagCEST asymmetry and T2 and T1ρ relaxation times were calculated for the femoral articular cartilage to assess sensitivity to OA severity. Volumetric gagCEST imaging had higher gagCEST asymmetry than single-slice acquisitions (p = 0.015). The average scan-rescan coefficient of variation was 6.8%. There were no significant differences in average gagCEST asymmetry between younger and older healthy controls (p = 0.655) or between healthy controls and OA subjects (p = 0.310). T2 and T1ρ relaxation times were elevated in OA subjects (p < 0.001 for both) compared with healthy controls and both were moderately correlated with total KOOS scores (rho = -0.181 and rho = -0.332 respectively). The gagCEST technique developed here, with volumetric scan times under 10 min and high gagCEST asymmetry at 3 T, did not vary significantly between healthy subjects and those with mild-moderate OA. This further supports a limited utility for gagCEST imaging at 3 T for assessment of early changes in cartilage composition in OA.
View details for DOI 10.1002/nbm.4310
View details for PubMedID 32445515
Assessing the Effectiveness of Evidence-Based Medicine in Practice A Case Study of First-Time Anterior Shoulder Dislocations
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
2019; 101 (2): e6
The dissemination of evidence-based information into medical practice is essential to provide patients with optimal care and realize society's substantial investments in medical research. Effective information delivery and treatment utilization may lead to improvements in patient outcome, reductions in cost, and an overall lower burden on the health-care system. This study examines the dissemination of medical evidence following a first-time anterior shoulder dislocation (FTASD) and assesses the impact of potential dissemination strategies.The state of evidence dissemination into clinical practice for FTASD was evaluated with use of the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. The treatment pathway for patients with FTASDs was mapped and evaluated using data that were collected through an orthopaedic shoulder-specialist survey and with review of a claims database.A total of 1,755 patients with an FTASD were identified through a national claims database; 50% of patients followed up with a care provider within 30 days after an emergency department (ED) or urgent care visit. Based on shoulder-specialist survey data, physician estimates of the risk of redislocation within a 2-year window aligned with medical evidence 59% of the time. Only 29% of patients obtained information for FTASD that aligns with high-level medical evidence.There are gaps and deficiencies in the dissemination and application of evidence in the treatment of FTASDs. Specifically, patients have limited exposure to health-care encounters where appropriate information related to low rates of follow-up following ED or urgent care visits may be communicated. Evaluating the current state of practice and identifying areas of improvement for the dissemination of evidence regarding FTASDs can be achieved through application of the RE-AIM framework. Greater consideration and resourcing of dissemination and implementation strategies may improve the dissemination and the impact of existing medical evidence.
View details for DOI 10.2106/JBJS.17.01588
View details for Web of Science ID 000458570700002
View details for PubMedID 30653051
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