Current Research and Scholarly Interests
My research is devoted to the advancement of imaging sciences for applications in diagnostic radiology. We collaborate closely with departmental clinicians and with others in the school of medicine, humanities, and the engineering sciences.
Presently my research is directed in part towards exploration of rapid scanning methods using spiral and other non-Cartesian k-space trajectories. Using spiral techniques, we have developed MRI pulse sequences and processing methods for mapping cortical brain function by imaging the metabolic response to various stimuli, with applications in the basic neurosciences as well as for clinical applications. These methods develop differential image contrast from hemodynamically driven increases in oxygen content in the vascular bed of activated cortex, using pulse sequences sensitive to the paramagnetic behavior of deoxyhemoglobin or to the blood flow changes. Multimodal imaging and neuromodulation combines fMRI with EEG, fPET, fNIRS, TES (TACS, TDCS, TMS) and HIFU.
