School of Medicine
Showing 11-20 of 38 Results
Clinical Assistant Professor, Pediatrics - Critical Care
Current Research and Scholarly Interests My research interests reside in the field of Neurocritical Care Medicine. My research focus has included inflammation following traumatic brain injury, outcome prediction after cardiac arrest, and neuro-monitoring in the pediatric intensive care setting. These interests are integrated clinically to focus on the merging of specialized neurologic monitoring and care with prognostic efforts in critically ill patients.
Associate Professor of Biology
Current Research and Scholarly Interests Cardiovascular developmental biology
Associate Professor of Epidemiology and Population Health, of Medicine (Primary Care and Population Health) and, by courtesy, of Sociology
Bio I am a social epidemiologist and serve as an Associate Professor in the Department of Epidemiology and Population Health and in the Department of Medicine in the Division of Primary Care and Population Health. I joined the faculty at Stanford School of Medicine in 2011.
I am currently the co-director of the Stanford Center for Population Health Sciences. In this position I am committed to making high value data resources available to researchers across disciplines in order to better enable them to answer their most pressing clinical and population health questions.
My own research is focused on understanding the health implications of the myriad decisions that are made by corporations and governments every day - decisions that profoundly shape the social and economic worlds in which we live and work. While these changes are often invisible to us on a daily basis, these seemingly minor actions and decisions form structural nudges that can create better or worse health at a population level. My work demonstrates the health implications of corporate and governmental decisions that can give the public and policy makers evidence to support new strategies for promoting health and well-being. In all of his work, I have a focus on the implications of these exposures for health inequalities.
Since often policy and programmatic changes can take decades to influence health, my work also includes more basic research in understanding biological signals that may act as early warning signs of systemic disease, in particular accelerated aging. I examine how social and economic policy changes influence a range of early markers of disease and aging, with a particular recent focus on DNA methylation. I am supported by several grants from the National Institute on Aging and the National Institute on Minority Health and Health Disparities to develop new more sensitive ways to understand the health implications of social and economic policy changes.
Richard J. Reimer, MD
Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology at the Palo Alto Veterans Administration Health Care System
Current Research and Scholarly Interests Reimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters – vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders.
Allan L. Reiss
Howard C. Robbins Professor of Psychiatry and Behavioral Sciences and Professor of Radiology
Current Research and Scholarly Interests My laboratory, the Center for Interdisciplinary Brain Sciences Research (CIBSR), focuses on multi-level scientific study of individuals with typical and atypical brain structure and function. Data are obtained from genetic analyses, structural and functional neuroimaging studies, assessment of endocrinological status, neurobehavioral assessment, and analysis of pertinent environmental factors. Our overarching focus is to model how brain disorders arise and to develop disease-specific treatments.
David A. Relman
Thomas C. and Joan M. Merigan Professor and Professor of Microbiology and Immunology
Current Research and Scholarly Interests My investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.
Malte Renz, MD, PhD
Instructor, Obstetrics & Gynecology - Gynecologic Oncology
Current Research and Scholarly Interests I am interested in cell motility and molecular dynamics. I believe that intra- and intercellular molecular dynamics, compartmentalization, and complex formation may differentiate disease from normal beyond the expression level of proteins and may constitute relevant pathomechanisms. The tools I am using are quantitative fluorescence live-cell microscopy on the ensemble and single-molecule level. I aim to bridge direct patient care and basic research.
Instructor, Cardiovascular Institute
Bio Dr. Rhee is a general cardiologist with specialized clinical and research training in cardiovascular drug toxicity and pharmacogenomics. She completed clinical cardiology fellowship and internal medicine residency training at Stanford University School of Medicine. During her post-doctoral training, Dr. Rhee's research focused on elucidating cardiotoxic effects of iron overload and of multiple chemotherapeutic agents using patient-specific induced pluripotent stem cells (iPSCs) derived models. Her current research employs clinical data, population genomics, and patient-derived iPSCs models to study genetic determinants and mechanisms of drug-induced cardiovascular toxicities. Dr. Rhee's clinic sees cardio-oncology patients and focuses on devising new methods for minimizing cardiovascular complications in that population.
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly Interests The auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.