Current Research and Scholarly Interests
My research is focused on developing magnetic resonance imaging (MRI) methods that probe brain tissue microstructure. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neuronavigation, neurosurgical planning and the development of improved biomarkers for brain development, degeneration, disease and injury.
Active projects include:
- development of q-space trajectory imaging methods for probing tissue microstructure
- development of diffusion MRI methods for mapping cortical fiber patterns
- comparisons of MRI with CLARITY 3D histology
- development of a mixed-reality neuronavigation system for TMS
- leveraging 7T MRI for predicting healthy versus pathological aging
- developing diffusion tractography-based neurosurgical targeting methods
