Zinc: Roles in pancreatic physiology and disease.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
2020; 20 (7): 1413–20
Zinc is an essential trace element. Deficiencies are frequently seen with gastrointestinal diseases, including chronic pancreatitis, nutritional deficiency, and reduced intestinal absorption. Additionally, reduced zinc levels have been linked to cellular changes associated with acute pancreatitis such as enhanced inflammation with increased macrophage activation and production of inflammatory cytokines such as IL-1β, impaired autophagy, and modulation of calcium homeostasis. Preliminary data suggest that zinc deficiency may lead to pancreatic injury in animal models. The purpose of this review is to explore the biologic effects of zinc deficiency that could impact pancreatic disease. MESH KEYWORDS: Malnutrition, inflammation, trace element.
View details for DOI 10.1016/j.pan.2020.08.016
View details for PubMedID 32917512
View details for PubMedCentralID PMC7572834