School of Medicine
Showing 201-300 of 356 Results
Associate Professor of Biology
Current Research and Scholarly Interests Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.
Professor of Radiology (Radiological Sciences Lab)
Current Research and Scholarly Interests MR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests Dr. Mudumbai?s research interests focus on 1) optimizing therapeutic strategies and reducing adverse outcomes related to medication management, particularly opioids; and 2) measuring and improving the quality of perioperative and pain management.
Scientific Education and Outreach Program Coordinator, Cardiovascular Institute Operations
Current Role at Stanford Scientific Education and Outreach Program Coordinator
Associate Professor of Surgery (Pediatric Surgery) at the Stanford University Medical Center
Current Research and Scholarly Interests Investigations of how children's beliefs of health affect their responses to illness.
Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital and at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Murphy's major interests are in noninvasive cardiology and clinical pediatric and adult congenital cardiac disease. These clinical interests range from imaging of complex cardiac disease in the fetus and newborn to care of the adult with congenital heart disease. He also coordinates the Marfan clinic at LPCH. He is the director of the Adult Congenital Cardiac Clinic at Stanford University Medical Center.
Kari Nadeau, MD, PhD
Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma, Professor of Pediatrics, Senior Fellow at the Woods Institute and Professor, by courtesy, of Otolaryngology and of Epidemiology and Population Health at LPCH
Current Research and Scholarly Interests Dr. Kari Nadeau?s laboratory and clinical research is focused on understanding the role of genes and the environment, including climate change, on the rising incidence of allergies and asthma. By understanding the genetic, epigenetic, cellular, and humoral factors that mediate immune tolerance or allergy to foods, aeroallegens, and air pollutants (e.g., diesel emissions and wildfires), her research is laying the groundwork for potential future therapies to prevent and cure allergies and asthma.
Hiromitsu (Hiro) Nakauchi
Professor of Genetics (Stem Cell)
Current Research and Scholarly Interests Translation of discoveries in basic research into practical medical applications
Professor of Radiology (Integrative Biomedical Imaging Informatics) and, by courtesy, of Medicine (Medical Informatics) and of Electrical Engineering
Current Research and Scholarly Interests My research seeks to advance the clinical and basic sciences in radiology, while improving our understanding of biology and the manifestations of disease, by pioneering methods in the information sciences that integrate imaging, clinical and molecular data. A current focus is on content-based radiological image retrieval and integration of imaging features with clinical and molecular data for diagnostic, prognostic, and therapy planning decision support.
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Narayan directs the Computational Arrhythmia Research Laboratory, whose goal is to define the mechanisms underlying complex human heart rhythm disorders, to develop bioengineering-focused solutions to improve therapy that will be tested in clinical trials. The laboratory has been funded continuously since 2001 by the National Institutes of Health, AHA and ACC, and interlinks a disease-focused group of clinicians, computational physicists, bioengineers and trialists.
Professor of Mechanical Engineering
Bio Research involves development of improved methods for predicting the fatigue life of engineering materials, incuding the effects of manufacturing processes, and investigation of new approaches in the field of experimental mechanics, such as determination of residual stresses using optical methods.
Stanford University Professor in Pulmonary and Critical Care Medicine
Current Research and Scholarly Interests Our lab focuses primarily on the contribution of the immune response to lung disease. We are specifically examining the contribution of inflammation to the development of vascular injury in transplantation, pulmonary hypertension and lymphedema.
Associate Professor of Medicine (Cardiovascular Medicine) and of Radiology (CV Imaging) at the Stanford University Medical Center
Current Research and Scholarly Interests Dr Nieman investigates advanced cardiac imaging techniques. Current projects focus on the development of functional CT application for hemodynamic interpretation of coronary artery disease, and the clinical validation of cardiac CT in the management of patients with ischemic heart disease.
Addie and Al Macovski Professor in the School of Engineering
Current Research and Scholarly Interests medical imaging, magnetic resonance imaging
Casual - Non-Exempt, Cardiovascular Institute Operations
Bio Board Certified in Plastic and Reconstructive Surgery (Japan)
Director, Spectrum, Senior Associate Dean, Research and Lowell W. and Josephine Q. Berry Professor
Current Research and Scholarly Interests Dr. O'Hara's research aims to investigate how cognitive information processing deficits subserve affective symptoms in psychiatric disorders, and interact with key brain networks integral to these disorders. To do so, she has implemented a translational, interdisciplinary program that encompasses cellular models, brain and behavioral assays of affective and cognitive information processing systems in psychiatric disorders across the lifespan.
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) at the Stanford University Medical Center
Current Research and Scholarly Interests I am primarily working at the Cardiovascular Institute (Director Joseph Wu, MD, PhD), studying the effect of different anesthetics on human induced pluripotent stem cells (hiPSC). Considering the current opioid epidemic, I am currently focusing on the effect of chronic opioid exposure on endothelial and cardiac function.
Associate Professor of Epidemiology and Population Health
Bio Michelle Odden, PhD, is an Associate Professor of Epidemiology in the Department of Health Research and Policy. Her research aims to improve our understanding of the optimal preventive strategies for chronic disease in older adults, particularly those who have been underrepresented in research including the very old, frail, and racial/ethnic minorities. Her work has focused on prevention of cardiovascular and kidney outcomes, as well as preservation of physical and cognitive function in older adults. She is also strongly interested in epidemiological and statistical methods to reduce biases in observational studies. Dr. Odden came to Stanford from Oregon State University, where she helped build the new College of Public Health and Human Sciences. She completed her Ph.D. in Epidemiology from the University of California, Berkeley (2009), a postdoctoral fellowship at the University of California, San Francisco in Primary Care Research (2011).
Roy B. Cohn-Theodore A. Falasco Professor in Cardiothoracic Surgery
Current Research and Scholarly Interests Development of an artificial heart assist device; heart, and heart-lung transplantation.
David T. Paik
Instructor, Cardiovascular Institute
Bio Dr. David Paik is instructor working with Dr. Joseph Wu at Stanford Cardiovascular Institute. At Stanford, his focus is to utilize single-cell RNA-sequencing technology to elucidate patient-specific mechanisms of various cardiovascular diseases, characterize embryonic heart development, and optimize differentiation of iPSCs to subtypes of cardiovascular cells. Dr. Paik received his BA in Biochemistry and Molecular Biology at Boston University (2010) and PhD in Cell and Developmental Biology at Vanderbilt University (2015). At Vanderbilt, Dr. Paik investigated the endogenous cardiac repair mechanisms in the adult heart following ischemic injury such as myocardial infarction, with focus on the role of Wnt signaling pathway on coronary vessel formation and plasticity of endothelial cells during cardiac tissue repair. During his PhD training, Dr. Paik completed HHMI/VUMC Certificate Program in Molecular Medicine, where he was supervised by his clinical mentor Dr. Douglas Sawyer to interact with congestive heart failure patients and to bridge clinical sciences with basic and translational cardiovascular research. Dr. Paik is currently supported by the NIH NHLBI K99/R00 Pathway to Independence Award.
Latha Palaniappan, MD, MS
Professor of Medicine (Primary Care and Population Health) and, by courtesy, of Epidemiology and Population Health at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Palaniappan has published over 200 peer reviewed manuscripts, abstracts, and book chapters over the last 20 years in the areas of chronic disease prevention and treatment in diverse populations. She has expertise in epidemiological research using big data, use of electronic health records for research, and clinical trials.
Postdoctoral Research Fellow, Cardiovascular Institute
Bio Dr. Paul Pang is a postdoctoral fellow at the Stanford Cardiovascular Institute with research interests in disease modeling, clinical genomics, precision medicine, and drug discovery. Dr. Pang received his Ph.D. in Integrative Molecular and Biomedical Sciences studying the alternative splicing of SCN5A in the heart and the effects of its misregulation in diseases such as myotonic dystrophy. During his Ph.D. training, he was a recipient of the NIH T32 and F31 NRSA Predoctoral Fellowships, Claude W. Smith Fellowship Award, and Dean's Award of Excellence among numerous presentation and travel awards from the Muscular Dystrophy Association and the American Heart Association. During his postdoctoral training, Dr. Pang has been awarded NIH T32 and F32 NRSA Postdoctoral Fellowships to investigate muscular dystrophies with a focus on personalized medicine and drug discovery.
Alan C. Pao
Assistant Professor of Medicine (Nephrology) and, by courtesy, of Urology at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly Interests We are interested in how the kidneys control salt, water, and electrolyte homeostasis in the body. We use cultured kidney cells, transgenic mice, and human samples to study hormonal and signal transduction pathways that control epithelial ion transport. Clinical implications of our work include a better understanding of the pathogenesis of salt-sensitive hypertension and kidney stone formation and growth.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Dr. Parikh is cardiologist specializing in the care of patients with inherited cardiovascular diseases. She completed clinical cardiology fellowship at Stanford School of Medicine and her medical residency at the University of California, San Francisco. Funded by research grant from the NIH, she currently studies multiple causes of cardiomyopathy in the laboratory. She has a particular clinical and scientific interest in inherited arrhythmogenic cardiomyopathies, which are an increasingly recognized disease entity. Dr. Parikh is currently using patient cohort genetics, high throughput molecular biology and human induced pluripotent stem cell derived cardiomyocytes to study variant pathogenicity in this disease.
John M. Pauly
Reid Weaver Dennis Professor
Bio Interests include medical imaging generally, and magnetic resonance imaging (MRI) in particular. Current efforts are focused on medical applications of MRI where real-time interactive imaging is important. Two examples are cardiac imaging, and the interactive guidance of interventional procedures. Specific interests include rapid methods for the excitation and acquisition of the MR signal, and the reconstruction of images from the data acquired using these approaches.
Dr. Richard K. and Erika N. Richards Professor
Current Research and Scholarly Interests Mechanims (molecular and cellular) of pulmonary hypertension, treatment of pulmonary hypertension, treatment of respiratory failure, treatment of septic shock, hemodynamic monitoring
Boston Scientific Applied Biomedical Engineering Professor and Professor of Radiology, Emeritus
Current Research and Scholarly Interests Broadly, Dr. Pelc is interested in the physics, engineering and mathematics of medical imaging, especially computed tomography, digital x-ray imaging, magnetic resonance imaging, and hybrid multimodality systems. His current research is concentrated in the development of computed tomography systems with higher image quality and dose efficiency, in the characterization of system performance, and in the development and validation of new clinical applications.
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Dr. Marco Perez's research goal is to better understand the fundamental causes of cardiovascular disease through the study of genetics and epidemiology. His group studies the genetic variations and environmental exposures that are associated with conditions such as atrial fibrillation and heart failure. He has led the studies of atrial fibrillation in Women's Health Initiative, one of the largest nation-wide population-based cohorts. He is currently conducting a large study monitoring for silent or asymptomatic atrial fibrillation in women from the WHI randomized to exercise intervention, and is co-PI in the Apple Heart Study, a clinical trial using the Apple Watch to screen for atrial fibrillation. He is interested in understanding the paradox that atrial fibrillation is less common in African Americans and Hispanics, despite a greater burden of risk factors such as hypertension. As director of the Stanford Inherited Arrhythmia Clinic, he evaluates families with rare inherited arrhythmias associated with sudden death such as Long QT and Brugada Syndromes and explores their links with novel genes. He is particularly interested in studying the genetic causes of very early onset atrial fibrillation. He also studies how best to use the electrocardiogram to identify patients at risk for atrial fibrillation and athletes at risk for life-threatening arrhythmias due to conditions such as hypertrophic cardiomyopathy. His genetic studies have led to the discovery of promising novel therapeutic targets that his group is now studying at a functional level. Dr. Perez receives funding from NIH/NHLBI (R01), Apple Inc., the Weston Havens Foundation, The Stanford Cardiovascular Division and the Stanford SPARK program.
Associate Professor of Electrical Engineering
Current Research and Scholarly Interests Our research focuses on providing theoretical foundations and engineering platforms for realizing electronics that seamlessly integrate with the body. Such systems will allow precise recording or modulation of physiological activity, for advancing basic scientific discovery and for restoring or augmenting biological functions for clinical applications.
Sutardja Chuk Professor of Definitive and Curative Medicine
Bio Dr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in ?History and Science? at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled ?Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.? He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled ?Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.? After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children?s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren?s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing?a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children?s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
Assistant Professor of Radiation Oncology (Radiation Physics)
Current Research and Scholarly Interests The Physical Oncology Lab is interested in making a lasting impact on translational cancer research by building novel physical tools and methods.
Adjunct Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly Interests The Priest lab seeks a better understanding of the genetics and pathogenesis of congenital heart disease using translational genomics, big-data, and vertebrate models of cardiac development.
Lee Otterson Professor in the School of Engineering and Professor of Bioengineering, of Applied Physics and, by courtesy, of Physics
Current Research and Scholarly Interests Single molecule biophysics, precision force measurement, micro and nano fabrication with soft materials, integrated microfluidics and large scale biological automation.
Thomas Quertermous, MD
William G. Irwin Professor in Cardiovascular Medicine
Current Research and Scholarly Interests Understanding genetic basis of cardiovascular function and disease.
Professor of Emergency Medicine at the Stanford University Medical Center
Current Research and Scholarly Interests Dr. Quinn's primary focus is emergency care research with previous experience running large multi-center trials.. He has an extensive research background in clinical decision making involving patients with syncope and in the development and clinical evaluation of tissue adhesives. He is currently focused on the use of machine learning and artificial intelligence algorithms to augment physician decision making and personalizing the care of patients.
Dwight and Vera Dunlevie Professor in Pediatric Cardiology
Current Research and Scholarly Interests Our research program seeks to identify the cellular and molecular programs regulating vascular and lung development, through the use of cultured cells and tissues and mouse and rat models. We then determine how these programs are perturbed by genetic abnormalities or injurious processes associated with disease, focusing on pulmonary arterial hypertension (PAH), a fatal complication in children with heart defects, and a condition of unknown etiology primarily in young women.
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric) at the Stanford University Medical Center
Current Research and Scholarly Interests Neuro protection and neurologic outcomes in cardiac patients prior to and concurrent with cardiac surgery and catheterization
Thomas Rando, MD, PhD
Professor of Neurology
Current Research and Scholarly Interests Our laboratory studies the molecular mechanisms regulating stem cell function, the effects of aging on skeletal muscle and skeletal muscle stem cells, and the pathogenesis and experimental therapeutics for hereditary muscle diseases, specifically the muscular dystrophies.
Natalie L. Rasgon
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) at the Stanford University Medical Center, Emerita
Current Research and Scholarly Interests Dr. Rasgon has been involved in longitudinal placebo-controlled neuroendocrine studies for nearly two decades, and she has been involved in neuroendocrine and brain imaging studies of estrogen effects on depressed menopausal women for the last eight years. It should be noted that in addition to her duties as a Professor of Psychiatry and Obstetrics & Gynecology, Dr. Rasgon is also the Director of the Behavioral Neuroendocrinology Program and of the Women's Wellness Program.
Associate Professor of Biology
Current Research and Scholarly Interests Cardiovascular developmental biology
Associate Professor of Cardiothoracic Surgery at the Stanford University Medical Center and the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests 1. Mechanical circulatory support in failing Fontan circulation
2. Pathophysiologic response to fetal cardiac surgery.
3. Various clinical projects in pediatric cardiothoracic surgery
Instructor, Cardiovascular Institute
Bio Dr. Rhee is a general cardiologist with specialized clinical and research training in cardiovascular drug toxicity and pharmacogenomics. She completed clinical cardiology fellowship and internal medicine residency training at Stanford University School of Medicine. During her post-doctoral training, Dr. Rhee's research focused on elucidating cardiotoxic effects of iron overload and of multiple chemotherapeutic agents using patient-specific induced pluripotent stem cells (iPSCs) derived models. Her current research employs clinical data, population genomics, and patient-derived iPSCs models to study genetic determinants and mechanisms of drug-induced cardiovascular toxicities. Dr. Rhee's clinic sees cardio-oncology patients and focuses on devising new methods for minimizing cardiovascular complications in that population.
Associate Professor of Electrical Engineering and Senior Fellow at the Precourt Institute for Energy
Current Research and Scholarly Interests Modern applications demand power capabilities beyond what is presently achievable. High performance systems need high power density and bandwidth that are difficult to achieve.
Power density can be improved with better semiconductors and passive componets, and by reducing the energy storage requirements of the system. By dramatically increasing switching frequency it is possible to reduce size of power converters. I'm interested in high performance/frequency circuits switching >10 MHz.
The Irving Schulman, M.D. Endowed Professor in Child Health, Professor of Medicine (Stanford Prevention Research Center) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests Dr. Robinson originated the solution-oriented research paradigm and directs the Stanford Solutions Science Lab. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy.
Stanley G. Rockson, MD
Allan and Tina Neill Professor of Lymphatic Research and Medicine
Current Research and Scholarly Interests My clinical research includes studies on risk factor modification in atherosclerosis and coronary artery disease; clinical trials involving medical therapies for peripheral arterial insufficiency; coronary angiogenesis; therapy of lymphedema; atherand photodynamic therapy in atherosclerosis.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Fatima Rodriguez, MD, MPH is an Assistant Professor in Cardiovascular Medicine and (by courtesy) the Stanford Prevention Research Center. She received her MD and MPH from Harvard and completed her cardiovascular fellowship at Stanford. She has expertise in cardiovascular prevention and promoting health equity in cardiovascular care and research. She completed her residency at Brigham and Women's Hospital and a fellowship in Cardiovascular Medicine at Stanford University. She specializes in common cardiac conditions such as coronary artery disease, valvular heart disease, lipid disorders, and cardiovascular risk assessment in high-risk populations.
Dr. Rodriguez?s research includes a range of topics relating to racial, ethnic, and gender disparities in cardiovascular disease prevention and developing novel interventions to address disparities.
Associate Professor of Medicine (Pulmonary and Critical Care) at the Stanford University Medical Center
Current Research and Scholarly Interests We use genetics and genomics methodologies to identify novel ARDS pathobiology; we hope that this will enable identification of novel biomarkers, phenotypes, and treatments for the disease. We are building a plasma biobank of critically ill patients at Stanford, with a particular focus on metabolic changes in critical illness.
Associate Professor of Biochemistry and of Medicine (Oncology)
Current Research and Scholarly Interests the overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.
Professor of Pediatrics (Pediatric Cardiology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Research interests include the study of Heart Failure, Cardiomyopathy and ventricular dysfunction in children, from a clinical perspective. Investigations include clinical trials of medications, cardiac resynchronization, and mechanical circulatory support.
Elsie Gyang Ross
Assistant Professor of Surgery (Vascular Surgery) and of Medicine (BMIR) at the Stanford University Medical Center
Bio Dr. Ross is a vascular surgeon and research scientist. She graduated from Stanford University School of Medicine in 2011 and completed her vascular surgery 0+5 residency at Stanford University School of Medicine in 2018. During her residency, she completed a two-year post-doctoral fellowship in biomedical informatics. Her current research focuses on using machine learning and electronic health records for early disease identification, precision medicine, and evaluating opportunities to engage in patient education beyond the clinic.
Stephen J. Roth
Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Randomized Therapeutic Trials in Pediatric Heart Disease, NIH/U01 GrantNo. HL68285 2001-2006.
Heparin and the Reduction of Thrombosis (HART) Study. Pediatric Health Research Fund Award, Stanford Univ Sch of Medicine, 2005-2006.
A Pilot Trial fo B-type Natriuretic Peptide for Promotion of Urine Output in Diuretic-Resistant Infants Following Cardiovascular Surgery.Pediatric Health Research Fund Award, Stanford Univ Sch of Medicine, 2005-2006.
Professor of Biomedical Data Science and of Radiology (Integrative Biomedical Imaging Informatics at Stanford), of Medicine (Biomedical Informatics Research) and, by courtesy, of Ophthalmology and of Computer Science
Current Research and Scholarly Interests My research interest is imaging informatics--ways computers can work with images to leverage their rich information content and to help physicians use images to guide personalized care. Work in our lab thus lies at the intersection of biomedical informatics and imaging science.
Karim Sallam, MD
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Karim Sallam, MD, is trained in Cardiovascular Medicine and Advanced Heart Failure.
Nazish Sayed MD, PhD
Assistant Professor (Research) of Surgery (Vascular Surgery) and at the Stanford Cardiovascular Institute
Current Research and Scholarly Interests The Sayed Laboratory is focused on the development of novel technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. The lab conducts translational research in vascular biology and aims to understand the role of the vasculature in the development of cardiac diseases, including those due to inherited genetic variants or environmental insults such as type 2 diabetes or hypertension. The lab employs the human induced pluripotent stem cell (iPSC) technology to generate patient-specific vascular cells (endothelial and vascular smooth muscle cells) as an alternative to animal models providing a human tissue surrogate for research that is scalable and sustainable. By employing this unique platform, the lab also investigates the role of chemotherapeutic agents (anti-cancer drugs) on the vasculature. Dr. Sayed?s lab has also established an endothelial regeneration program, where they leverage the innate immune system to regenerate endothelial cells from human fibroblasts.
Work from the lab has led to seminal discoveries in the areas of 1) Nitric oxide (NO) biology, (2) vascular biology, (3) stem cell biology, (4) cardiovascular disease modeling (5) cardio-oncology.
Ingela Schnittger, MD
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center
Current Research and Scholarly Interests My main research continues to be in the field of echocardiography. Several areas of research are currently being pursued.
Associate Professor of Emergency Medicine at the Stanford University Medical Center, Emeritus
Current Research and Scholarly Interests My research group focuses on the diagnosis and treatment of cardiovascular emergencies including acute myocardial infarction, acute coronary syndrome and congestive heart failure. We have evaluated novel cardiac markers and point-of-care testing in clinical practice. Current projects also include the diagnosis and treatment of acute pulmonary embolism and deep venous thrombosis. Other interests include spinal cord injury, pneumonia and sepsis.
John S. Schroeder, MD
Professor (Clinical) of Medicine (Cardiovascular)
Current Research and Scholarly Interests 1. Clinical Pharmocology of Cardiovascular Drugs
(a) Calcium Channel Blockers
(b) Agents for Heart Failure
(c) Anti-atherosclerotic Effects of Cardiovascular Drugs, e.g. Calcium Channel Blockers
2. Cardiac Transplantation/Congestive Heart Failure
3. Coronary Artery Spasm
Assistant Professor (Research) of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests The thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. My long-term goals are: 1. Understanding the biology of germ cells and and their ability to sustain early preimplantation development; 2. Understanding the mechanisms that regulate very early cell fate decisions in human embryos; 3. Understanding the biology of derivation and maintenance of Pluripotent Stem Cells
Professor of Radiology and, by courtesy, of Medicine (Cardiovascular) at the Palo Alto Veterans Administration Health Care System
Current Research and Scholarly Interests Scintigraphic evaluation of coronary blood flow and myocardial function using single photon emission computed tomography (SPECT) and positron emission tomography (PET). Tumor imaging and characterization of pulmonary nodules with PET/CT.
Zachary M. Sellers, MD, PhD
Assistant Professor of Pediatrics (Gastroenterology) at the Lucile Salter Packard Children's Hospital
Bio I am a pediatric physician-scientist striving to advance cystic fibrosis clinical care and translational research. Clinically, I am focused on gastrointestinal manifestations of cystic fibrosis, developing diagnostic and therapeutic modalities to improve the gastrointestinal and liver health of those with cystic fibrosis. I also specialize in the clinical management of pediatric pancreatitis and am involved with the international INSPPIRE consortium to study pediatric pancreatitis. My research spans the entire spectrum across basic science and translational research to clinical research and trials. In the laboratory, my projects are centered around understanding mechanisms of ion transport in cystic fibrosis tissues and determining how loss of CFTR ion transport leads to pathologic changes in human physiology. We are also very interested in the pathophysiological relationship between pancreatitis and intestinal diseases, such as inflammatory bowel disease. Our laboratory has expertise in epithelial ion transport, with specialized skills in the measurement of bicarbonate transport. We are also part of a Multi-PI collaboration pursuing CFTR gene editing and stem cell engraftment for the treatment of cystic fibrosis. We utilize a combination of immortalized and primary cell culture, organoids, mouse and human tissue, and whole animal in vivo studies.
Nigam H. Shah, MBBS, PhD
Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly Interests We analyze multiple types of health data (EHR, Claims, Wearables, Weblogs, and Patient blogs), to answer clinical questions, generate insights, and build predictive models for the learning health system.
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy) and of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly Interests Transplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.
Professor of Cardiothoracic Surgery at the Stanford University Medical Center
Current Research and Scholarly Interests In clinical research, Dr. Shrager has been an innovator studying outcomes in a variety of areas within Thoracic Surgery including: parenchyma-sparing operations and minimally invasive resections for lung cancer, transcervical thymectomy for myasthenia gravis, and surgical treatment of emphysema.
In the lab, Dr. Shrager is focused on the impact of disease states upon the diaphragm. His group published the seminal paper (NEJM) describing diaphragm atrophy assoc'd with mechanical ventilation.
Associate Professor of Epidemiology and Population Health and, by courtesy, of Medicine (Immunology & Rheumatology)
Bio Julia Fridman Simard, ScD, is an Associate Professor of Epidemiology & Population Health, and, by courtesy, of Medicine in Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Simard earned her Masters and Doctorate of Science in Epidemiology degrees at the Harvard School of Public Health. During that time she trained with investigators at the Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy at Brigham and Women?s Hospital and the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center. In 2008, Dr. Simard relocated to Sweden to begin a Postdoctoral Fellowship in Clinical Epidemiology at the Karolinska Institutet in Stockholm. She became an Assistant Professor in their Clinical Epidemiology Unit in 2011, and was later honored with a Karolinska Institutet Teaching Award. Leveraging the population-based registers of Sweden, Dr. Simard initiated a national register linkage study to examine the utility of registers in Systemic Lupus Erythematosus (SLE) research and develop an extensive data repository for future epidemiologic investigations.
While maintaining a close collaboration with the Karolinska Institutet, she joined Stanford?s Epidemiology faculty as an Assistant Professor in 2013. Dr. Simard studies outcomes such as malignancy, stroke, infection, and mortality, in patients with systemic autoimmune rheumatic diseases, but her primary research focus has shifted to the intersection between reproductive epidemiology and rheumatic disease. In 2014 she was awarded a five-year K career development award from the NIH (NIAMS) to study maternal and fetal outcomes in systemic lupus pregnancy. This fueled a number of collaborations with colleagues at Stanford, throughout the US, and abroad, and a series of projects focused on the diagnosis of preeclampsia and associated risks in pregnant women with systemic lupus. Dr. Simard was recently awarded a Peter Joseph Pappas Research Grant from the Preeclampsia Foundation for her lab's work examining preeclampsia risk in high-risk populations, and a McCormick Faculty Award from Stanford Medicine to take important steps towards disentangling preeclampsia from lupus nephritis. In addition to these issues of misclassification in reproductive rheumatology questions, Dr. Simard's lab is also interested in how misclassification, missed opportunities, and misdiagnosis contribute to disparities in complex conditions such as SLE. In addition to methodologic issues around misclassification and bias and the largely clinical epi focus of her work, Dr. Simard's work examines social determinants of health and health disparities.
Current Research and Scholarly Interests Cholesterol in biological membranes; genetic mechanisms & cholesterol production
Stanford W. Ascherman, MD, FACS, Professor in Genetics
Current Research and Scholarly Interests Our laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states
Associate Professor of Medicine (Pulmonary and Critical Care Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Pulmonary Arterial Hypertension
Pulmonary Vascular Remodeling
Modulation of BMP signaling
BMP signaling in health and disease in the right ventricle of the heart
"BMP signature" in blood as a biomarker
BMP signaling in neonatal chronic lung disease
Douglass M. and Nola Leishman Professor of Cardiovascular Disease
Current Research and Scholarly Interests The general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.
Marcia L. Stefanick, Ph.D.
Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests Marcia L. Stefanick, Ph.D is a Professor of Medicine Professor of Obstetrics and Gynecology, and by courtesy, Professor of Epidemiology and Population Health at Stanford University School of Medicine. Dr. Stefanick?s research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. She is currently the Principal Investigator the Women?s Health Initiative (WHI) Extension Study, having been the PI of the Stanford Clinical Center of the landmark WHI Clinical Trials and Observational Study since 1994 and Chair of the WHI Steering and Executive Committees from 1998-2011, as well as PI of the WHI Strong and Healthy (WHISH) Trial which is testing the hypothesis that a DHHS-based physical activity intervention, being delivered to a multi-ethnic cohort of about 24,000 WHI participants across the U.S., aged 68-99 when the trial started in 2015, will reduce major cardiovascular events over 8 years, compared to an equal number of ?usual activity? controls. Dr. Stefanick is also PI of the Osteoporotic Study of Men (MrOS) which is continuing to conduct clinical assessments of bone and body composition in survivors of an original cohort of nearly 6000 men aged 65 and over in 2001. As founding Director of the Stanford Women?s Health and Sex Differences in Medicine (WHSDM, ?wisdom?) Center, she plays a major role in promoting research and teaching on Sex and Gender in Human Physiology and Disease, Women?s Health and Queer Health and Medicine. Dr. Stefanick also plays major leadership roles at the Stanford School of Medicine, including as co-leader of the Population Sciences Program of the Stanford Cancer Institute, Stanford?s NCI-funded comprehensive cancer center.
Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology, with exercise physiology as a secondary focus. Her commitment to human research led to a post-doctoral fellowship in Cardiovascular Disease Prevention at the Stanford Prevention Research Center, which has been her academic home for nearly 40 years.
Professor of Genetics
Current Research and Scholarly Interests We apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
Katrin J Svensson
Assistant Professor of Pathology
Current Research and Scholarly Interests Molecular metabolism
Cell biology and function
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Current Research and Scholarly Interests Program Overview
The world we enjoy, including the oxygen we breathe, has been beneficially created by biological systems. Consequently, we believe that innovative biotechnologies can also serve to help correct a natural world that non-natural technologies have pushed out of balance. We must work together to provide a sustainable world system capable of equitably improving the lives of over 10 billion people.
Toward that objective, our program focuses on human health as well as planet health. To address particularly difficult challenges, we seek to synergistically combine: 1) the design and evolution of complex protein-based nanoparticles and enzymatic systems with 2) innovative, uniquely capable cell-free production technologies.
To advance human health we focus on: a) achieving the 120 year-old dream of producing ?magic bullets?; smart nanoparticles that deliver therapeutics or genetic therapies only to specific cells in our bodies; b) precisely designing and efficiently producing vaccines that mimic viruses to stimulate safe and protective immune responses; and c) providing a rapid point-of-care liquid biopsy that will count and harvest circulating tumor cells.
To address planet health we are pursuing biotechnologies to: a) inexpensively use atmospheric CO2 to produce commodity biochemicals as the basis for a new carbon negative chemical industry, and b) mitigate the intermittency challenges of photovoltaic and wind produced electricity by producing hydrogen either from biomass sugars or directly from sunlight.
More than 25 years ago, Professor Swartz began his pioneering work to develop cell-free biotechnologies. The new ability to precisely focus biological systems toward efficiently addressing new, ?non-natural? objectives has proven tremendously useful as we seek to address the crucial and very difficult challenges listed above. Another critical feature of the program is the courage (or naivete) to approach important objectives that require the development and integration of several necessary-but- not-sufficient technology advances.
Daniel Sze, MD, PhD
Professor of Radiology (Interventional Radiology) at the Stanford University Medical Center
Current Research and Scholarly Interests Transarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections
Associate Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Dr. Teuteberg is board certified in Cardiology and Heart Failure and Transplantation. He is currently the Section Chief of Heart Failure, Cardiac Transplantation, and Mechanical Circulatory Support. He sees patients both in the clinic and in the hospital with advanced heart failure and who have received cardiac transplantation or mechanical circulatory support.
His research interests are in clinical outcomes in patients after transplant and mechanical support as well as novel approaches to immunosuppression. He has participated in many single-center and multi-institutional research studies and has published widely in the fields of transplant and mechanical support. He served as President of the International Society of Heart and Lung Transplantation in 2018.