School of Medicine
Showing 1-100 of 469 Results
Oliver O. Aalami, MD
Clinical Professor, Surgery - Vascular Surgery
Current Research and Scholarly Interests We launched a national precision medicine PAD trial called, VascTrac (http://vasctrac.stanford.edu/). This trial is mobile phone based and leverages Apple's ResearchKit Platform to monitor a patient's activity both pre- and post-intervention. We are validating mobile phone surveillance for PAD patients and are currently enrolling.
Administrative Director, Vera Moulton Wall Center for Pulmonary Vascular Disease, CVI/Vera Moulton Wall Center
Current Role at Stanford Administrative Director, Vera Moulton Wall Center for Pulmonary Vascular Disease at Stanford
Oscar J. Abilez
Senior Research Scientist - Basic Life, Cardiovascular Institute Operations
Current Research and Scholarly Interests Dr. Abilez' interests are aimed at elucidating how various biophysical and biochemical perturbations regulate early cardiovascular development across time and length scales that span several orders of magnitude, using human pluripotent stem cells as a model system.
Kevin M. Alexander, MD, FACC, FHFSA
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Bio Dr. Alexander is an advanced heart failure-trained cardiologist. He is also an Assistant Professor of Cardiovascular Medicine at Stanford University School of Medicine.
Dr. Alexander specializes in the management of advanced heart failure and transplant cases, seeing a wide range of patients. He also has an active research laboratory, studying various forms of heart failure.
Dr. Alexander has expertise in diagnosing and treating transthyretin cardiac amyloidosis, a critical yet underdiagnosed cause of heart failure among African Americans and the elderly. He is conducting extensive research to enhance our understanding of this condition, with grant support from the National Institutes of Health and American Heart Association, among other sources.
Russ B. Altman
Kenneth Fong Professor and Professor of Bioengineering, of Genetics, of Medicine (General Medical Discipline), of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly Interests I refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/
Cristina M. Alvira
Associate Professor of Pediatrics (Critical Care)
Current Research and Scholarly Interests The overall objective of the Alvira Laboratory is to elucidate the mechanisms that promote postnatal lung development and repair, by focusing on three main scientific goals: (i) identification of the signaling pathways that direct the transition between the saccular and alveolar stages of lung development; (ii) exploration of the interplay between postnatal vascular and alveolar development; and (iii) determination of developmentally regulated pathways that mediate lung repair after injury.
Professor of Neurology
Current Research and Scholarly Interests Our research focuses on understanding how immune responses initiate and accelerate synaptic and neuronal injury in age-related neurodegeneration, including models of Alzheimer's disease and Parkinson's disease. We also focus on the role of immune responses in aggravating brain injury in models of stroke. Our goal is the identification of critical immune pathways that function in neurologic disorders and that can be targeted to elicit disease modifying effects.
Timothy Angelotti MD, PhD
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD)
Current Research and Scholarly Interests My research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly Interests Our laboratory's current transformative research efforts focus on studying immune health in the context of surgery and anesthesia.
Justin P. Annes M.D., Ph.D.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly Interests The ANNES LABORATORY of Molecular Endocrinology: Leveraging Chemical Biology to Treat Endocrine Disorders
The prevalence of diabetes is increasing at a staggering rate. By the year 2050 an astounding 25% of Americans will be diabetic. The goal of my research is to uncover therapeutic strategies to stymie the ensuing diabetes epidemic. To achieve this goal we have developed a variety of innovate experimental approaches to uncover novel approaches to curing diabetes.
(1) Beta-Cell Regeneration: Diabetes results from either an absolute or relative deficiency in insulin production. Our therapeutic strategy is to stimulate the regeneration of insulin-producing beta-cells to enhance an individual?s insulin secretion capacity. We have developed a unique high-throughput chemical screening platform which we use to identify small molecules that promote beta-cell growth. This work has led to the identification of key molecular pathways (therapeutic targets) and candidate drugs that promote the growth and regeneration of islet beta-cells. Our goal is to utilize these discoveries to treat and prevent diabetes.
(2) The Metabolic Syndrome: A major cause of the diabetes epidemic is the rise in obesity which leads to a cluster of diabetes- and cardiovascular disease-related metabolic abnormalities that shorten life expectancy. These physiologic aberrations are collectively termed the Metabolic Syndrome (MS). My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity. We aim to manipulate these hormone levels to prevent the development and detrimental consequences of the MS.
HEREDIATY PARAGAGLIOMA SYNDROME
The Hereditary Paraganglioma Syndrome (hPGL) is a rare genetic cancer syndrome that is most commonly caused by a defect in mitochondrial metabolism. Our goal is to understand how altered cellular metabolism leads to the development of cancer. Although hPGL is uncommon, it serves as an excellent model for the abnormal metabolic behavior displayed by nearly all cancers. Our goal is to develop novel therapeutic strategies that target the abnormal behavior of cancer cells. In the laboratory we have developed hPGL mouse models and use high throughput chemical screening to identify the therapeutic susceptibilities that result from the abnormal metabolic behavior of cancer cells.
As a physician scientist trained in clinical genetics I have developed expertise in hereditary endocrine disorders and devoted my efforts to treating families affected by the hPGL syndrome. By leveraging our laboratory expertise in the hPGL syndrome, our care for individuals who have inherited the hPGL syndrome is at the forefront of medicine. Our goal is to translate our laboratory discoveries to the treatment of affected families.
Assistant Professor of Material Science and Engineering, by courtesy, of Pediatrics (Endocrinology) and Center Fellow, by courtesy, at the Woods Institute for the Environment
Current Research and Scholarly Interests The underlying theme of the Appel Lab at Stanford University integrates concepts and approaches from supramolecular chemistry, natural/synthetic materials, and biology. We aim to develop supramolecular biomaterials that exploit a diverse design toolbox and take advantage of the beautiful synergism between physical properties, aesthetics, and low energy consumption typical of natural systems. Our vision is to use these materials to solve fundamental biological questions and to engineer advanced healthcare solutions.
Associate Professor of Electrical Engineering
Current Research and Scholarly Interests My group's research covers RF circuits and system design for (1) biomedical, (2) sensing, and (3) Internet of Things (IoT) applications.
Associate Professor of Surgery (Vascular Surgery)
Bio Shipra Arya, MD SM FACS is an Associate Professor of Surgery at the Stanford University School of Medicine and section chief of vascular surgery at VA Palo Alto Healthcare System. She has a Master?s degree in epidemiology from the Harvard School of Public Health with focus on research methodology and cardiovascular epidemiology. She completed her General Surgery Residency at Creighton University Medical Center followed by a Vascular Surgery Fellowship at University of Michigan. She has been funded by American Heart Association (AHA), NIH/NIA GEMSSTAR grant, VA Palo Alto Center for Innovation and Implementation (Ci2i) and is currently funded by VA HSR&D. The accumulated evidence from her research all points to the fact that frailty is a versatile tool that can be utilized to guide surgical decision making, inform patient consent and design quality improvement initiatives at the patient and hospital level. The field of frailty research in surgical population is still relatively nascent and her current work focuses on streamlining frailty evaluation, and implementation of patient and system level interventions to improve surgical outcomes and enhance patient centered care.
Euan A. Ashley
Associate Dean, School of Medicine, Roger W. and Joelle G. Burnell Professor of Genomics and Precision Health, Professor of Medicine, of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Current Research and Scholarly Interests The Ashley lab is focused on precision medicine. We develop methods for the interpretation of whole genome sequencing data to improve the diagnosis of genetic disease and to personalize the practice of medicine. At the wet bench, we take advantage of cell systems, transgenic models and microsurgical models of disease to prove causality in biological pathways and find targets for therapeutic development.
Themistocles (Tim) Assimes
Associate Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests Genetic Epidemiology, Genetic Determinants of Complex Traits related to Cardiovasular Medicine, Coronary Artery Disease related pathway analyses and integrative genomics, Mendelian randomization studies, risk prediction for major adverse cardiovascular events, cardiovascular medicine related pharmacogenomics, ethnic differences in the determinants of Insulin Mediated Glucose Uptake, pharmacoepidemiology of cardiovascular drugs & outcomes
David M. Axelrod, MD
Clinical Professor, Pediatrics - Cardiology
Current Research and Scholarly Interests Virtual Reality Congenital Heart Disease experience: The Stanford Virtual Heart. Currently engaged with 19 academic medical centers across the globe using our Stanford Virtual Heart to educate students and trainees, and research our VR experience as a means for training and education. Also developing next generation modeling and image interaction with Stanford engineers and educators, to promote personalized surgical training in VR and advanced educational programs in congenital heart disease.
Dan E. Azagury, MD, FACS
Associate Professor of Surgery (General Surgery)
Current Research and Scholarly Interests .
Associate Professor of Cardiothoracic Surgery (Thoracic Surgery)
Bio Leah Backhus trained in general surgery at the University of Southern California and cardiothoracic surgery at the University of California Los Angeles. She practices at Stanford Hospital and is Chief of Thoracic Surgery at the VA Palo Alto. Her surgical practice consists of general thoracic surgery with special emphasis on thoracic oncology and minimally invasive surgical techniques. She is also Co-Director of the Thoracic Surgery Clinical Research Program, and has grant funding through the Veterans Affairs Administration and NIH. Her current research interests are in imaging surveillance following treatment for lung cancer and cancer survivorship. She is a member of the National Lung Cancer Roundtable of the American Cancer Society serving as Chair of the Task Group on Lung Cancer in Women. She also serves on the Board of Directors of the Society of Thoracic Surgeons. As an educator, Dr. Backhus is the Associate Program Director for the Thoracic Track Residency and is the Chair of the ACGME Residency Review Committee for Thoracic Surgery which is the accrediting body for all cardiothoracic surgery training programs in the US.
Professor of Genetics
Current Research and Scholarly Interests We examine how cells communicate and function during fetal development. The work in my laboratory focuses on the establishment of specific cell fates using genomics to decipher interactions between chromatin and developmental signaling cascades, between genomes and rapidly evolving cell types, and between genomic copy number variation and gene expression. In recent years we have focused on the vastly understudied biology of the trophoblast lineage, particularly how this lineage evolved.
Bing Professor of Human Biology and Senior Fellow at the Stanford Institute for Economic Policy Research
Current Research and Scholarly Interests Dr. Baker's research is in the area of health economics, and focuses on the effects of financial incentives, organizational structures, and government policies on the health care delivery system, health care costs, and health outcomes.
Hans-Christoph Becker, MD, FSABI, FSCCT
Clinical Professor, Radiology
Current Research and Scholarly Interests Myocardial bridges (MB) with associated upfront atherosclerotic lesions are common findings on coronary computed tomography angiography (CTA). Abnormal septal wall motion in exercise echocardiography (EE) may to be associated with MB. Intravascular ultrasound (IVUS) is considered the gold standard for the detection of MB. We investigate whether CTA is comparable to IVUS for the assessment of MB and upstream plaques in symptomatic patients with suspicion for MB raised by EE.
Professor of Developmental Biology, of Computer Science, of Pediatrics (Genetics) and of Biomedical Data Science
Current Research and Scholarly Interests Dr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. His research focuses on genome sequence and function in both humans and related primate, mammalian and vertebrate species. He is deeply interested in mapping both coding and non-coding genome sequence variation to phenotype differences, and in extracting specific genetic insights from high throughput sequencing measurements, in the contexts of development and developmental abnormalities.
Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics
Current Research and Scholarly Interests 1. Using iPSC-derived cardiomyocytes to understand hypertrophic cardiomyopathy and heart failure associated with congenital heart disease.
2. Role of alterations in mitochondrial dycamics and function in normal physiology and disease.
3. Differences between R and L ventricular responses to stress,
4. Immune biomarkers of risk after pediatric VAD implantation.
5. Biomarkers for post-transplant lymphoproliferative disorder.
Professor of Pathology
Current Research and Scholarly Interests Cardiopulmonary and pulmonary transplant medicine; diagnostic surgical pathology
Vivek Bhalla, MD
Associate Professor of Medicine (Nephrology)
Current Research and Scholarly Interests Dr. Bhalla's two primary research interests are in the role of the kidney in diabetes and hypertension. We use molecular, biochemical, and transgenic approaches to study: (1) mechanisms diabetic kidney disease disease including the role of the endothelium to regulate inflammation and kidney injury; and (2) regulation of tubular transport of glucose, sodium, and potassium. These latter studies have treatment implications in diabetes, kidney disease, and hypertension.
Associate Professor of Medicine (Hematology) and of Genetics
Current Research and Scholarly Interests The Bhatt lab is exploring how the microbiota is intertwined with states of health and disease. We apply the most modern genetic tools in an effort to deconvolute the mechanism of human diseases.
Y. Katherine Bianco
Clinical Associate Professor, Obstetrics & Gynecology - Maternal Fetal Medicine
Bio My clinical interest in pregnancies complicated with birth defects has led my underlying research interests in genomic abnormalities in the human trophoblast carrying to faulty placentation. The latter began with initial work during K12 and KO8 funding. I took a great interest in the human placenta as it carries potential advantages over other tissues sources: first, this highly metabolically active organ is the potential source of many transcripts. Second, the placenta forms at a very early stage of embryonic development, potentially allowing detection of primary alterations as compared to secondary changes that may mask the underlying causal phenomena. Finally, studying early placentation may provide targets for development of novel molecular approaches, such as up-regulate or down-regulate genes, the protein products of which could potentially serve as molecular surrogates for diagnosis and treatment of pregnancy complication such as miscarriages, pre-eclampsia, pregnancy induced hypertension and intrauterine growth retardation. This work has led to the first Trisomy 21, Trisomy 18, trisomy 13 cell lines established from human placentas making it possible to apply gene editing in the early stages of human trophoblast development.
As my primary clinical responsibility involves treating patients needing medical care and support through their high risk pregnancies, I am interested in factors that may impact outcomes, such as prenatal screening and diagnosis, maternal heart conditions, labor and delivery management, and safety approaches for the second stage of labor. In investigating length of labor and approaches to shorten the second stage, I have found methods of improving perinatal outcomes in diverse maternal populations.
With regards to my interest in fetal medicine, I have worked in collaboration with other specialists such as radiologists and pediatric cardiologists utilizing imagining studies to assess and determine successful perinatal care and fetal survival.
Sandip Biswal, MD
Associate Professor of Radiology (Musculoskeletal Imaging)
Current Research and Scholarly Interests The management of individuals suffering from chronic pain is unfortunately limited by poor diagnostic tests and therapies. Our research group is interested in 'imaging pain' by using novel imaging techniques to study peripheral nociception and inflammation with the goal of accurately identifying the location of pain generators. We are developing new approaches with positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET/MRI) and are currently in clinical trials.
Professor (Research) of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly Interests Our research focuses on the pathogenesis and treatment of acute and chronic neonatal lung injury and the mechanisms that regulate lung fluid balance and alveolar & pulmonary vascular development after premature birth.
Associate Professor of Radiology (Pediatric Radiology) and, by courtesy, of Pediatrics
Current Research and Scholarly Interests Studies on apoptotic cell death in vivo using the H MRS phenomenon.
Professor of Medicine and of Molecular Pharmacology, Emeritus
Current Research and Scholarly Interests Clinical pharmacology of antiretroviral drugs
Pharmacokinetic and pharmacodynamic mechanisms of variability in drug response.
Helen M. Blau
Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology and Professor, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly Interests The Bollyky Lab studies the immunology of chronic bacterial infections with an emphasis on Pseudomonas aeruginosa wound and lung infections in Diabetes and Cystic Fibrosis. Areas of particular interest include bacteriophages, biofilms, and host-pathogen interactions. Our goals are to gain insight into fundamental disease mechanisms and to generate novel therapies to improve human health.
Postdoctoral Research Fellow, Cardiovascular Institute
Current Research and Scholarly Interests One gene can lead to the production of many different RNA isoforms via mechanisms such as alternative promoter usage, splicing, and polyadenylation. The functional significance of many of these isoforms, their impact on cell physiology, and their regulation remain mostly controversial. Understanding the functional consequences of transcript heterogeneity will improve our understanding of gene expression regulation, broadening our ability to intervene when mutations that interfere with this regulation cause human disease.
My goal is to become an independent researcher leading an academic lab that focuses on better understanding human tissue-specific post-transcriptional regulation of gene expression and developing mechanism-based therapeutics. My general strategy is to study the function of regulatory genes and their deregulation in human disease. My specific approach is to understand the molecular mechanisms by which disease-causing mutations alter the gene function and lead to human disease. My hypothesis is that a detailed understanding of the relationship between the gene's molecular function and the disease mechanism will allow the development of first-in-class, personalized therapeutic strategies that target the disease mechanisms rather than manage symptoms independently of disease etiology.
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly Interests Clinical Education
Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER)
Anesthesia for transcatheter and electrophyiology procedures
Michele and Timothy Barakett Endowed Professor
Current Research and Scholarly Interests Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
Marion S. Buckwalter, MD, PhD
Professor of Neurology and of Neurosurgery
Current Research and Scholarly Interests The goal of the Buckwalter Lab is to improve how people recover after a stroke. We use basic research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how to make recovery faster and better after stroke.
Professor of Cardiothoracic Surgery (Adult Cardiac Surgery)
Current Research and Scholarly Interests New technologies in the area of catheters, clamps, and, visualization devices for aid in cardiac surgery; distribution of, cardioplegia, both anterograde and retrograde as determined by, techniques in technetium pyro-phosphate scans; glucose insulin, potassium as an adjunct in cardiac surgery.
Professor of Biomedical Data Science, of Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests My genetics research focuses on analyzing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. We focus on novel methods development for complex disease genetics and risk prediction in multi-ethnic settings. I am also interested in clinical data science and development of new diagnostics.I am also interested in disruptive innovation for healthcare including modeling long-term risk shifts and novel payment models.
Klaus Bensch Professor of Pathology
Current Research and Scholarly Interests Our interests include:
1) The physiology and function of lymphocyte homing in local and systemic immunity;
2) Biochemical and genetic studies of molecules that direct leukocyte recruitment;
3) Chemotactic mechanisms and receptors in vascular and immune biology;
4) Vascular control of normal and pathologic inflammation and immunity;
5) Systems biology of immune cell trafficking and programming in tumor immunity.
Professor of Genetics, Emerita
Current Research and Scholarly Interests My lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.
We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.
We are working on 3 forms of muscular dystrophy.
We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.
Clinical Associate Professor, Surgery - Vascular Surgery
Bio Dr. Chandra is a board certified vascular surgeon who specializes in cutting edge approaches to aortic aneurysmal disease, peripheral vascular disease and limb salvage.
Andrew Young Chang, MD
Ph.D. Student in Epidemiology and Clinical Research, admitted Summer 2020
Current Research and Scholarly Interests My research interests center around the epidemiology, environmental determinants, and health services dimensions of heart disease, with an emphasis on vulnerable populations, both international and domestic. Current projects include the development of novel care quality metrics for use in rheumatic heart disease in East Africa, testing of low sodium salt substitutes in South Asia, and describing the cardiovascular impacts of cyclical climate change-associated major environmental events.
Steven D. Chang, MD
Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology
Current Research and Scholarly Interests Clinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.
Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.
Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.
Tara I. Chang
Associate Professor of Medicine (Nephrology)
Current Research and Scholarly Interests My research focuses on issues such as blood pressure control, coronary revascularization, and the comparative effectiveness of cardioprotective medications in patients with chronic kidney disease, with the long-term goal of improving cardiovascular outcomes in these high-risk patients.
Associate Director of Strategic Research Development, Cardiovascular Institute Operations
Current Role at Stanford As a Grant Writer and Project Coordinator at the CVI, Dr. Chase:
?Provides grantsmanship support to CVI faculty and postdoctoral fellows
?Edits and critically evaluates grant applications and manuscripts
?Develops communication pieces to promote publications from CVI faculty
Associate Professor of Mechanical Engineering
Bio Our group's research is focused at the intersection of mechanics and biology. We are interested in elucidating the underlying molecular mechanisms that give rise to the complex mechanical properties of cells, extracellular matrices, and tissues . Conversely, we are investigating how complex mechanical cues influence important biological processes such as cell division, differentiation, or cancer progression. Our approaches involve using force measurement instrumentation, such as atomic force microscopy, to exert and measure forces on materials and cells at the nanoscale, and the development of material systems for 3D cell culture that allow precise and independent manipulation of mechanical properties.
Adjunct Professor, Surgery - Vascular Surgery
Current Research and Scholarly Interests Our research laboratory focuses on understanding the mechanics of the cardiovascular system, especially with respect to interactions between medical devices and the dynamic cardiovascular environment. We use medical imaging, 3D geometric modeling, and custom deformation quantification techniques to investigate disease processes and medical device performance. We are interested in the dynamics of the heart, aorta, and peripheral vasculature, and are always seeking ways to apply our research to current and emerging therapies. While our research pursuits seek to add to the fundamental understanding of cardiovascular biomechanics, all of our projects are directly related to improving medical device design, evaluation, regulation, and their use in clinical practice.
Glenn M. Chertow
Norman S. Coplon/Satellite Healthcare Professor of Medicine and Professor, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interests clinical epidemiology, health services research, decision sciences, clinical trials in acute and chronic kidney disease
Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly Interests My research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
Associate Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly Interests Neurological monitoring in critically ill infants. Altered hemodynamics in neonates, especially in relation to prematurity, congenital heart disease, and central nervous system injury. Determination of the hemodynamic significance and effects of a patent ductus arteriosus in the preterm infant. Utilizing NIRS (near-infrared spectroscopy) and other technologies for improved monitoring in the NICU.
Danny Hung-Chieh Chou
Assistant Professor of Pediatrics (Endocrinology)
Current Research and Scholarly Interests Our research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
William Clusin, MD
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests Cardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.
Jennifer R. Cochran
Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical Engineering
Current Research and Scholarly Interests Molecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology
Ronnie Thomas Collins
Clinical Associate Professor, Pediatrics - Cardiology
Current Research and Scholarly Interests My research endeavors are focused on populations with connective tissue disorders that manifest as cardiovascular abnormalities, such as Williams, Marfan, and Loeys-Dietz syndromes. Additionally, as a member of the California Center of BD-Steps II, I study birth defects associated with congenital heart disease.
Associate Professor of Pediatrics (Pulmonary Medicine)
Current Research and Scholarly Interests I am interested in studying the effects of inflammation in the lung, in particular, how N-acetylcysteine may affect and decrease that in CF patients. I am the PI of a multi-center study researching this question. Additionally, in a separate study involving children who have received lung transplants, I am a participating site in an NIH-sponsored observational and mechanistic multi-center study that will examine the role of viral infections in causing chronic graft rejection.
Christopher H. Contag
Professor of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly Interests We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.
David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine and Professor, by courtesy, of Surgery
Current Research and Scholarly Interests Over the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Our focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Current Research and Scholarly Interests Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.
Job and Gertrud Tamaki Professor of Chemistry
Current Research and Scholarly Interests We are developing various physical and chemical approaches to study biological processes in neurons. There are three major research directions: (1) Investigating the axonal transport process using optical imging, magnetic and optical trapping, and microfluidic platform; (2) Developing vertical nanopillar-based electric and optic sensors for sensitive detection of biological functions; (3) Using optogentic approach to investigate temporal and spatial control of intracellular signaling pathways.
Martha S. Cyert
Dr. Nancy Chang Professor
Current Research and Scholarly Interests The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin?s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly Interests Ultrasonic beamforming, imaging methods, systems, and devices.
The J.G. Jackson and C.J. Wood Professor of Chemistry
Bio Professor Dai?s research spans chemistry, physics, and materials and biomedical sciences, leading to materials with properties useful in electronics, energy storage and biomedicine. Recent developments include near-infrared-II fluorescence imaging, ultra-sensitive diagnostic assays, a fast-charging aluminum battery and inexpensive electrocatalysts that split water into oxygen and hydrogen fuels.
Born in 1966 in Shaoyang, China, Hongjie Dai began his formal studies in physics at Tsinghua U. (B.S. 1989) and applied sciences at Columbia U. (M.S. 1991). He obtained his Ph.D. from Harvard U and performed postdoctoral research with Dr. Richard Smalley. He joined the Stanford faculty in 1997, and in 2007 was named Jackson?Wood Professor of Chemistry. Among many awards, he has been recognized with the ACS Pure Chemistry Award, APS McGroddy Prize for New Materials, Julius Springer Prize for Applied Physics and Materials Research Society Mid-Career Award. He has been elected to the American Academy of Arts and Sciences, National Academy of Sciences (NAS), National Academy of Medicine (NAM) and Foreign Member of Chinese Academy of Sciences.
The Dai Laboratory has advanced the synthesis and basic understanding of carbon nanomaterials and applications in nanoelectronics, nanomedicine, energy storage and electrocatalysis.
The Dai Lab pioneered some of the now-widespread uses of chemical vapor deposition for carbon nanotube (CNT) growth, including vertically aligned nanotubes and patterned growth of single-walled CNTs on wafer substrates, facilitating fundamental studies of their intrinsic properties. The group developed the synthesis of graphene nanoribbons, and of nanocrystals and nanoparticles on CNTs and graphene with controlled degrees of oxidation, producing a class of strongly coupled hybrid materials with advanced properties for electrochemistry, electrocatalysis and photocatalysis. The lab?s synthesis of a novel plasmonic gold film has enhanced near-infrared fluorescence up to 100-fold, enabling ultra-sensitive assays of disease biomarkers.
Nanoscale Physics and Electronics
High quality nanotubes from his group?s synthesis are widely used to investigate the electrical, mechanical, optical, electro-mechanical and thermal properties of quasi-one-dimensional systems. Lab members have studied ballistic electron transport in nanotubes and demonstrated nanotube-based nanosensors, Pd ohmic contacts and ballistic field effect transistors with integrated high-kappa dielectrics.
Nanomedicine and NIR-II Imaging
Advancing biological research with CNTs and nano-graphene, group members have developed ??? stacking non-covalent functionalization chemistry, molecular cellular delivery (drugs, proteins and siRNA), in vivo anti-cancer drug delivery and in vivo photothermal ablation of cancer. Using nanotubes as novel contrast agents, lab collaborations have developed in vitro and in vivo Raman, photoacoustic and fluorescence imaging. Lab members have exploited the physics of reduced light scattering in the near-infrared-II (1000-1700nm) window and pioneered NIR-II fluorescence imaging to increase tissue penetration depth in vivo. Video-rate NIR-II imaging can measure blood flow in single vessels in real time. The lab has developed novel NIR-II fluorescence agents, including CNTs, quantum dots, conjugated polymers and small organic dyes with promise for clinical translation.
Electrocatalysis and Batteries
The Dai group?s nanocarbon?inorganic particle hybrid materials have opened new directions in energy research. Advances include electrocatalysts for oxygen reduction and water splitting catalysts including NiFe layered-double-hydroxide for oxygen evolution. Recently, the group also demonstrated an aluminum ion battery with graphite cathodes and ionic liquid electrolytes, a substantial breakthrough in battery science.
Ronald L. Dalman MD
Dr. Walter C. Chidester Professor
Current Research and Scholarly Interests Vascular biology, arterial remodeling, aneurysm development; innovative treatment strategies for AAA, animal models of arterial disease, arterial remodeling and flow changes in spinal cord injury, genetic regulation of arterial aneurysm formation
Rajesh Dash, MD PhD; Director of SSATHI & CardioClick
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly Interests I have two research areas:
1) Heart disease in South Asians - genetic, metabolic, & behavioral underpinnings of an aggressive phenotype.
2) Imaging cell injury & recovery in the heart. Using Cardiac MRI to visualize signals of early injury and facilitating preventive medical therapy. Optimizing new imaging methods for viable cells to delineate live heart cells or transplanted stem cells.
Ruth G. and William K. Bowes Professor in the School of Engineering and Professor, by courtesy, of Surgery
Bio Dauskardt and his group have worked extensively on integrating new materials into emerging technologies including thin-film structures for nanoscience and energy technologies, high-performance composite and laminates for aerospace, and on biomaterials and soft tissues in bioengineering. His group has pioneered methods for characterizing adhesion and cohesion of thin films used extensively in device technologies. His research on wound healing has concentrated on establishing a biomechanics framework to quantify the mechanical stresses and biologic responses in healing wounds and define how the mechanical environment affects scar formation. Experimental studies are complimented with a range of multiscale computational capabilities. His research includes interaction with researchers nationally and internationally in academia, industry, and clinical practice.
Mark M. Davis
Director, Stanford Institute for Immunity, Transplantation and Infection and the Burt and Marion Avery Family Professor
Current Research and Scholarly Interests Molecular mechanisms of lymphocyte recognition and differentiation; Systems immunology and human immunology; vaccination and infection.
Vinicio de Jesus Perez MD
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests My work is aimed at understanding the molecular mechanisms involved in the development and progression of pulmonary arterial hypertension (PAH). I am interested in understanding the role that the BMP and Wnt pathways play in regulating functions of pulmonary endothelial and smooth muscle cells both in health and disease.
Professor of Medicine, Emeritus
Current Research and Scholarly Interests Experimental and clinical epidemiology of myocardial, infarction; exercise testing; cardiac risk factor management;, cardiac rehabilitation; systems for patient management; ischemic, heart disease; computer-based expert systems.
Professor of Radiology (Canary Cancer Center) and, by courtesy, of Electrical Engineering
Bio Dr. Demirci is currently a Professor with tenure at Stanford University School of Medicine and Principal Investigator of the Demirci Bio-Acoustic MEMS in Medicine (BAMM) Lab at the Canary Center at Stanford for Cancer Early Detection. He received his B.S. degree in Electrical Engineering in 1999 as a James B. Angell Scholar (summa cum laude) from University of Michigan, Ann Arbor. He received his M.S. degree in 2001 in Electrical Engineering, M.S. degree in Management Science and Engineering in 2005, and Ph.D. in Electrical Engineering in 2005, all from Stanford University.
BAMM Lab specializes in applying micro- and nanoscale technologies to problems in medicine and early cancer detection at the interface between micro/nanoscale engineering and medicine. Our goal is to apply innovative technologies to clinical problems. Our major research theme focuses on creating new microfluidic technology platforms targeting broad applications in medicine. In this interdisciplinary space at the convergence of engineering, biology and materials science, we create novel technologies for disposable point-of-care (POC) diagnostics and monitoring of infectious diseases, cancer and controlling cellular microenvironment in nanoliter droplets for biopreservation and microscale tissue engineering applications. These applications are unified around our expertise to test the limits of cell manipulation by establishing microfluidic platforms to provide solutions to real world problems at the clinic.
Our lab creates technologies to manipulate cells in nanoliter volumes to enable solutions for real world problems in medicine including applications in infectious disease diagnostics and monitoring for global health, cancer early detection, cell encapsulation in nanoliter droplets for cryobiology, and bottom-up tissue engineering. Dr. Demirci has published over 120 peer reviewed publications in journals including PNAS, Nature Communications, Advanced Materials, Small, Trends in Biotechnology, Chemical Society Reviews and Lab-chip, over 150 conference abstracts and proceedings, 10+ book chapters, and an edited book. His work was highlighted in Wired Magazine, Nature Photonics, Nature Medicine, MIT Technology Review, Reuters Health News, Science Daily, AIP News, BioTechniques, and Biophotonics. He is fellow-elect of the American Institute of Biological and Medical Engineering (AIMBE, 2017). His scientific work has been recognized by numerous national and international awards including the NSF Faculty Early Career Development (CAREER) Award (2012), the IEEE-EMBS Early Career Achievement Award (2012), Scientist of the year award from Stanford radiology Department (2017). He was selected as one of the world?s top 35 young innovators under the age of 35 (TR-35) by the MIT Technology Review at the age of 28. In 2004, he led a team that won the Stanford University Entrepreneur?s Challenge Competition and Global Start-up Competition in Singapore. His work has been translated to start-up companies including DxNow, KOEK Biotechnology and LEVITAS. There has been over 10,000 live births in the US, Europe, Asia, and Middle East using the sperm selection technology that came out of Dr. Demirci's lab.
Associate Professor of Medicine (Pulmonary and Critical Care)
Current Research and Scholarly Interests We investigate the cellular and molecular events that regulate proper development of the lungs, including how the gas exchange region is maintained and renewed throughout life. We apply this knowledge to dissect how dysregulation of these normal processes can cause or contribute to specific lung diseases like pulmonary fibrosis, emphysema, and lung cancer, and we are interested in uncovering how lung stem cells are regulated in the hopes of harnessing them as a regenerative therapy for patients.
Gundeep Dhillon, MD, MPH
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests 1. Use of an administrative database (UNOS) to study lung transplant outcomes.
2. Expression of the plasminogen activator inhibitor (PAI) 1 antibody in peripheral blood after lung transplantation and its association with bronchiolitis obliterans syndrome (chronic rejection).
3. Impact of airway hypoxia, due to lack of bronchial circulation, on long-term lung transplant outcomes.
4. CMV specific T-cell immunity in lung transplant recipients and its impact on acute rejection.
Senior Associate Vice Provost for Research Platforms/Shared Facilities, Associate Professor of Materials Science and Engineering, Senior Fellow at the Precourt Institute for Energy and Associate Professor, by courtesy, of Radiology
Bio Jennifer Dionne is the Senior Associate Vice Provost of Research Platforms/Shared Facilities and an Associate Professor of Materials Science and Engineering and of Radiology (by courtesy) at Stanford. Jen received her Ph.D. in Applied Physics at the California Institute of Technology, advised by Harry Atwater, and B.S. degrees in Physics and Systems & Electrical Engineering from Washington University in St. Louis. Prior to joining Stanford, she served as a postdoctoral researcher in Chemistry at Berkeley, advised by Paul Alivisatos. Jen's research develops nanophotonic methods to observe and control chemical and biological processes as they unfold with nanometer scale resolution, emphasizing critical challenges in global health and sustainability. Her work has been recognized with the Alan T. Waterman Award (2019), an NIH Director's New Innovator Award (2019), a Moore Inventor Fellowship (2017), the Materials Research Society Young Investigator Award (2017), Adolph Lomb Medal (2016), Sloan Foundation Fellowship (2015), and the Presidential Early Career Award for Scientists and Engineers (2014), and was featured on Oprah?s list of ?50 Things that will make you say ?Wow!'"