School of Medicine
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Postdoctoral Research Fellow, Cardiovascular Medicine
Current Research and Scholarly Interests Heart transplant policy and outcomes, cost-effectiveness, mathematical modeling
Chad S. Weldy, M.D., Ph.D.
Postdoctoral Medical Fellow, Cardiovascular Medicine
Current Research and Scholarly Interests My long-term goal is to study the complex interaction between human genetic variants, environment, and epigenetic modifiers of transcriptional regulation to inform the discovery of novel treatments for cardiovascular disease.
My research thus far has focused upon understanding how genetics and environment interact to influence redox biology, transcriptional regulation, and epigenetic modifiers of cardiovascular disease. In my PhD work, I made discoveries on how impaired glutathione (GSH) biosynthesis impacts endothelial nitric oxide and vascular tone, and how there is a gene x environment interaction between the GSH synthesis gene Gclm in mediating pulmonary inflammation and systemic vasomotor responses to inhaled diesel exhaust air pollution. In my postdoctoral fellowship work, I made the discovery that in utero exposure to diesel exhaust air pollution increases adult susceptibility to pressure overload induced heart failure in mice using the transverse aortic constriction (TAC) model of heart failure. We further elucidated that this narrow exposure leads to oxidative stress within the placental vascular bed, which subsequently alters adult body weight, blood pressure, and changes global cardiac transcriptional response to TAC. This is mediated in part by altering cardiac DNA methylation profiles which are persistent until adulthood. This work was important to the field as it changed a paradigm by which we understand the effects of air pollution on cardiovascular disease. In addition, during my residency training I have investigated how changes in microRNA expression in circulating cells can reflect dynamic changes in RV function in adult patients with Tetralogy of Fallot, furthering my understanding of non-coding RNA and transcriptional regulation.