School of Medicine
Showing 1-50 of 56 Results
Laurie Kraus Lacob Director of the Stanford Cancer Institute (SCI), Jerome and Daisy Low Gilbert Professor and Professor of Biochemistry
Current Research and Scholarly Interests Telomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging. We are interested in how telomere shortening influences cancer, stem cell function, aging and human disease. Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer. We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches.
Professor of Radiation Oncology (Radiation and Cancer Biology) and of Genetics
Current Research and Scholarly Interests Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.
The Ernest and Amelia Gallo Professor, Professor of Urology, of Developmental Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Shirley R. and Leonard W. Ely, Jr. Professor of the School of Humanities and Sciences
Current Research and Scholarly Interests We use genetic, genomic and cell biological approaches to study cell fate acquisition, focusing on cases where cell fate is correlated with asymmetric cell division.
Helen M. Blau
Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology and Professor, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Michele and Timothy Barakett Endowed Professor
Current Research and Scholarly Interests Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
Howard Y. Chang, MD, PhD
Virginia and D. K. Ludwig Professor of Cancer Research and Professor of Genetics
Current Research and Scholarly Interests Our research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
Associate Professor of Medicine (Endocrinology, Gerontology and Metabolism)
Current Research and Scholarly Interests Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
Michael F. Clarke, M.D.
Karel H. and Avice N. Beekhuis Professor of Cancer Biology
Current Research and Scholarly Interests Dr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Current Research and Scholarly Interests Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.
Associate Professor of Medicine (Pulmonary and Critical Care)
Current Research and Scholarly Interests We investigate the cellular and molecular events that regulate proper development of the lungs, including how the gas exchange region is maintained and renewed throughout life. We apply this knowledge to dissect how dysregulation of these normal processes can cause or contribute to specific lung diseases like pulmonary fibrosis, emphysema, and lung cancer, and we are interested in uncovering how lung stem cells are regulated in the hopes of harnessing them as a regenerative therapy for patients.
Professor of Chemical and Systems Biology and of Biochemistry
Current Research and Scholarly Interests My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.
Associate Professor of Biology
Current Research and Scholarly Interests We study the evolution of complex traits by developing new experimental and computational methods.
Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation shapes the phenotypic diversity of life. Our main focus is on the evolution of gene expression, which is the primary fuel for natural selection. Our long-term goal is to be able to introduce complex traits into new species via genome editing.
Donald Kennedy Chair in the School of Humanities and Sciences and Professor of Genetics
Current Research and Scholarly Interests The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Margaret T. Fuller
Reed-Hodgson Professor of Human Biology and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly Interests Regulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.
Dr. Morris Herzstein Professor
Current Research and Scholarly Interests We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
Associate Professor of Genetics and, by courtesy, of Applied Physics
Current Research and Scholarly Interests Our lab focuses on developing methods to probe both the structure and function of molecules encoded by the genome, as well as the physical compaction and folding of the genome itself. Our efforts are split between building new tools to leverage the power of high-throughput sequencing technologies and cutting-edge optical microscopies, and bringing these technologies to bear against basic biological questions by linking DNA sequence, structure, and function.
Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry
Current Research and Scholarly Interests Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.
Andrew R. Hoffman
Professor of Medicine (Endocrinology)
Current Research and Scholarly Interests Mechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.
Peter K. Jackson
Professor of Microbiology and Immunology (Baxter Labs)
Current Research and Scholarly Interests Cell cycle and cyclin control of DNA replication .
Associate Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly Interests My laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.
Hanlee P. Ji
Associate Professor of Medicine (Oncology) and, by courtesy, of Electrical Engineering
Current Research and Scholarly Interests Cancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis
Paul A. Khavari, MD, PhD
Carl J. Herzog Professor of Dermatology in the School of Medicine
Current Research and Scholarly Interests We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.
Seung K. Kim M.D., Ph.D.
Professor of Developmental Biology and, by courtesy, of Medicine (Endocrinology) and of Pediatrics (Endocrinology)
Current Research and Scholarly Interests We study the development of pancreatic islet cells using molecular, embryologic and genetic methods in several model systems, including mice, pigs, human pancreas, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. These approaches have informed efforts to generate replacement islets from renewable sources for diabetes.
Paul and Mildred Berg Professor
Current Research and Scholarly Interests - Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly Interests We study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
Joseph (Joe) Lipsick
Professor of Pathology, of Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.
Assistant Professor of Developmental Biology (Stem Cell)
Current Research and Scholarly Interests We have developed a strategy to generate fairly pure populations of various human tissue progenitors in a dish from embryonic stem cells (ESCs). We have delineated the sequential lineage steps through which ESCs diversify into various tissues, and in so doing, developed methods to exclusively induce certain fates at the expense of others. The resultant pure populations of tissue progenitors are the fundamental building blocks for regenerative medicine.
M. Peter Marinkovich, MD
Associate Professor of Dermatology
Current Research and Scholarly Interests The Marinkovich lab studies the function of epithelial extracellular matrix molecules, including integrins, collagens and laminins in epithelial development and carcinoma progression. We apply our discoveries in this area towards development of molecular therapies for carcinomas, hair disease and inherited epithelial adhesive disorders.
Mrs. George A. Winzer Professor in Cell Biology
Current Research and Scholarly Interests CELLULAR INFORMATION PROCESSING. We are using live single-cell microscopy approaches to understand the design principles of cell signaling circuits. Mammalian signaling processes have a unique logic due to the large number of signaling proteins, second messengers and chromatin modifiers involved in each decision process. We are particularly interested in understanding how cells make decisions to enter and exit the cell cycle and how they decide to polarize and move.
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine, Emeritus
Current Research and Scholarly Interests Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.
Virginia and Daniel K. Ludwig Professor of Cancer Research and the Reed-Hodgson Professor of Human Biology
Current Research and Scholarly Interests Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.
Anthony Oro, MD, PhD
Eugene and Gloria Bauer Professor
Current Research and Scholarly Interests Our lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.
Donna Peehl, PhD
Professor (Research) of Urology, Emerita
Current Research and Scholarly Interests My research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.
Emma Pfeiffer Merner Professor of Medical Sciences
Current Research and Scholarly Interests The major focuses of our research is to understand the molecular basis of inherited Parkinson's Disease (PD) and to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in culture and specific regions of the brain.
Sylvia K. Plevritis, PhD
Professor of Biomedical Data Science and of Radiology (Integrative Biomedical Imaging Informatics at Stanford)
Current Research and Scholarly Interests My research program focuses on computational modeling of cancer biology and cancer outcomes. My laboratory develops stochastic models of the natural history of cancer based on clinical research data. We estimate population-level outcomes under differing screening and treatment interventions. We also analyze genomic and proteomic cancer data in order to identify molecular networks that are perturbed in cancer initiation and progression and relate these perturbations to patient outcomes.
Professor of Pathology
Current Research and Scholarly Interests Research in the Pollack lab centers on translational genomics, with a focus on human cancer. The lab employs next-generation sequencing, single-cell genomics, genome editing, and cell/tissue-based modeling to uncover disease mechanisms, biomarkers and therapeutic targets. Current areas of emphasis include diseases of the prostate (prostate cancer and benign prostatic hyperplasia), as well as odontogenic neoplasms.
Sutardja Chuk Professor of Definitive and Curative Medicine
Bio Dr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in ?History and Science? at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled ?Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.? He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled ?Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.? After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children?s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren?s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing?a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children?s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
Lei Stanley Qi
Assistant Professor of Bioengineering and of Chemical and Systems Biology
Bio Dr. Lei Stanley Qi is Assistant Professor in the Department of Bioengineering, Department of Chemical and Systems Biology, and a faculty fellow in Stanford ChEM-H. He is one of major contributors to the CRISPR technology development for genome engineering. He demonstrated the first use of the nuclease-deactivated Cas9 (dCas9) for genome targeting in cells. Using dCas9, His lab developed the CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) technologies for gene expression regulation, which is broadly used for high-throughput study of genomics in different organisms. He co-developed the CRISPR application for chromatin imaging in living cells. His lab greatly expanded the CRISPR toolbox for engineering the genome and epigenome, including multiplexed epigenome editing, programmable 3D genome manipulation (CRISPR-GO), live-cell imaging (LiveFISH), and CRISPR antivirals for targeting RNA viruses (PAC-MAN). He obtained B.S. in Physics from Tsinghua University, and Ph.D. in Bioengineering from the University of California Berkeley in 2012. He joined UCSF as Systems Biology Faculty Fellow between 2012 to 2014, and joined the faculty at Stanford University since 2014. His lab combines genome engineering with synthetic biology to understand the function of mammalian genomes and develop gene therapy.
Lee Otterson Professor in the School of Engineering and Professor of Bioengineering, of Applied Physics and, by courtesy, of Physics
Current Research and Scholarly Interests Single molecule biophysics, precision force measurement, micro and nano fabrication with soft materials, integrated microfluidics and large scale biological automation.
Associate Professor of Biochemistry and of Medicine (Oncology)
Current Research and Scholarly Interests the overall goal of my laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states, and to devise new strategies to repair their function.
Elaine and John Chambers Professor of Pediatric Cancer and Professor of Genetics
Current Research and Scholarly Interests We investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
Associate Professor of Biomedical Data Science and of Biochemistry
Current Research and Scholarly Interests Circular RNA regulation and function; computational and experimental approaches
Professor of Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests My overarching goal is to understand how cell growth triggers cell division. Linking growth to division is important because it allows cells to maintain specific size range to best perform their physiological functions. For example, red blood cells must be small enough to flow through small capillaries, whereas macrophages must be large enough to engulf pathogens. In addition to being important for normal cell and tissue physiology, the link between growth and division is misregulated in cancer.
Frank Lee and Carol Hall Professor, Senior Associate Vice Provost of Research and Professor of Genetics
Current Research and Scholarly Interests We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?
Aaron F. Straight
Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests We study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Professor of Urology, Emeritus
Current Research and Scholarly Interests We focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Professor of Chemical and Systems Biology and, by courtesy, of Chemistry
Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.