School of Medicine
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Daibhid O Maoileidigh
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly Interests The Ó Maoiléidigh group employs mathematical and computational approaches to better understand normal hearing and hearing impairment. Because complete restoration of auditory function by artificial devices or regenerative treatments will only be possible when experiments and computational modeling align, we work closely with experimental laboratories. Our goal is to understand contemporary experimental observations, to make experimentally testable predictions, and to motivate new experiments. We are pursuing several projects.
Auditory and balance organs rely on hair cells to convert mechanical vibrations into electrical signals for transmission to the brain. In response to the quietest sounds we can hear, the hair cell's mechanical sensor, the hair bundle, moves by less than one-billionth of a meter. To determine how this astounding sensitivity is possible, we construct computational models of hair-bundle mechanics. By comparing models with experimental observations, we are learning how a hair bundle's geometry, material properties, and ability to move spontaneously determine its function.
The cochlea contains the auditory organ that houses the sensory hair cells in mammals. Vibrations in the cochlea arising from sound are amplified more than a thousandfold by the ear's active process. New experimental techniques have additionally revealed that the cochlea vibrates in a complex manner in response to sound. We use computational models to interpret these observations and to make hypotheses about how the cochlea works.
Connor Galen O'Brien
Postdoctoral Medical Fellow, Cardiovascular Medicine
Bio Dr. O'Brien is a native of Menlo Park, CA. He attended medical school at Columbia University College of Physicians and Surgeons. At Columbia he was elected to both Alpha Omega Alpha and Gold Humanism Honors Societies. He completed an Internal Medicine residency as well as fellowship in Cardiovascular Medicine at Stanford University. In his third year of fellowship, he was selected Chief Cardiology Fellow.
He is currently a post-doctoral fellow performing regenerative medicine research, specifically studying the role of exosomes in treating cardiomyopathy. In addition to his basic science research, he is also involved in human clinical trials investigating the role of stem cells in treating various forms of cardiomyopathy.
Dale Gene O'Brien
Adjunct Clinical Assistant Professor, Medicine - Primary Care and Population Health
Bio Dale O?Brien, MD, MPH is adjunct faculty at the Stanford School of Medicine in the Primary Care and Population Health Division. He founded several medical clinics for vulnerable populations in underserved areas of northern California where he has engaged in more than a hundred thousand patient encounters as a practicing physician.
A 1973 graduate of the University of Missouri School of Medicine, he took postgraduate training at the Oregon Health & Science University, and the University of California Berkeley. He is board certified by the American Board of Family Medicine and by the American Board of Preventive Medicine.
Dr. O'Brien treated hippies at the White Bird Clinic in Eugene, Oregon in the mid-70s; served as the acting Health Officer of the Shasta County Health Department in California; and spent two years as an affiliate of the European Branch Headquarters of the World Health Organization in Denmark in the early 80s.
As the Executive Director of the nonprofit Cancer Patients Alliance (CPA) for the past two decades, Dr. O?Brien and his team have advocated for and supported low-income Latinx community members, immigrants and farm workers with cancer in the Salinas Valley agricultural region of Monterey County, California.
He is a member of the Stanford / Medable team that has received NIH/NCI_SBIR 363 Phase I and II grants beginning late 2017 and ongoing - to develop the cancer aftercare app called TOGETHERCare.
Dr. O?Brien and team were a part of the Stanford-based research group in 2018 that developed the behavioral health app for the CDC and Council of State and Territorial Epidemiologists that piloted as ?Healthkey.?
Since 2019, he has been a Co-Principal Investigator with the Stanford research group that received a 3-year award from the California Initiative to Advance Precision Medicine to help reduce cancer disparities in Monterey County.
In 2021 CPA with Dr. O?Brien as Project Executive Director received a 3-year grant from the Robert Wood Johnson Foundation to further their advocacy work with the Latinx community and farm workers with cancer in the Salinas Valley.
In June 2021, CPA with Dr. O'Brien as Principal was selected by the California GOTV medical academic consortium including Stanford as led by UCLA - to conduct the Get Out the Vaccine to Stop Covid-19 for low-income populations in Monterey County, California.
Since 2016 he has been on the IRB of Clinica de Salud del Valle de Salinas. He is currently a member of the Stanford Cancer Institute Community Advisory Board. Dr. O?Brien is a past editor of the Berkeley Wellness Letter, Medicine on the Net and Cancer Informatics.
Lucy Erin O'Brien
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests Many adult organs tune their functional capacity to variable levels of physiologic demand. Adaptive organ resizing breaks the allometry of the body plan that was established during development, suggesting that it occurs through different mechanisms. Emerging evidence points to stem cells as key players in these mechanisms. We use the Drosophila midgut, a stem-cell based organ analogous to the vertebrate small intestine, as a simple model to uncover the rules that govern adaptive remodeling.
Arline and Pete Harman Professor for the Chair in the Department of Pediatrics in the School of Medicine, Emeritus
Current Research and Scholarly Interests Clinical:
Pulmonary edema, acute respiratory distress syndromes (ARDS), hyaline membrane disease (HMD), bronchopulmonary dysplasia (BPD)
Lung epithelial sodium transport
Genetic influences on the development of BPD