Insights on cross-species transmission of SARS-CoV-2 from structural modeling
Insights on cross-species transmission of SARS-CoV-2 from structural modeling.
PLoS computational biology
2020; 16 (12): e1008449
Measurement of Marginal Placental Cord Insertion by Prenatal Ultrasound Was Found Not to Be Predictive of Adverse Perinatal Outcomes
Synesthetic colors induced by graphemes that have not been consciously perceived
2015; 21 (2): 216-219
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global pandemic that has infected more than 31 million people in more than 180 countries worldwide. Like other coronaviruses, SARS-CoV-2 is thought to have been transmitted to humans from wild animals. Given the scale and widespread geographical distribution of the current pandemic and confirmed cases of cross-species transmission, the question of the extent to which this transmission is possible emerges, as well as what molecular features distinguish susceptible from non-susceptible animal species. Here, we investigated the structural properties of several ACE2 orthologs bound to the SARS-CoV-2 spike protein. We found that species known not to be susceptible to SARS-CoV-2 infection have non-conservative mutations in several ACE2 amino acid residues that disrupt key polar and charged contacts with the viral spike protein. Our models also allow us to predict affinity-enhancing mutations that could be used to design ACE2 variants for therapeutic purposes. Finally, our study provides a blueprint for modeling viral-host protein interactions and highlights several important considerations when designing these computational studies and analyzing their results.
View details for DOI 10.1371/journal.pcbi.1008449
View details for PubMedID 33270653
Interpolation of illusory pain in the human somatosensory system
2012; 41 (7): 878-880
Grapheme-color synesthetes experience colors when they see printed letters of the alphabet. Currently, we tested four "projector" synesthetes, whose colors evoked by graphemes have sensory support or quale and appear to be restricted spatially to the letters like real colors. We use three different kinds of puzzle pictures that contained hidden letters, which require 30 s or more for nonsynesthetes to identify. Grapheme-color projector synesthetes recognize them three times faster and report that the colors were evoked before conscious letter recognition, clueing them as to what the letters were. Subjectively, the synesthetic subjects reported that they also saw mirror-reversed letters in the same colors as nonreversed letters which enabled them to read mirror-reversed text at thrice the normal speed. We conclude that in some synesthetes colors are evoked preconsciously early in sensory processing.
View details for DOI 10.1080/13554794.2014.890728
View details for Web of Science ID 000346850300013
View details for PubMedID 24621005
Graphemes evoke synesthetic colors even before they are consciously recognized
2011; 40 (4): 490-492
Three coins are lined up with the middle coin at room temperature and flanking coins cooled down to 4 degrees C. If digits 2 and 4 are placed on the outer coins and digit 3 on the middle coin, the latter also feels cold; a striking example of perceptual filling in of temperature. We show that if digits 2 and 4 are placed on a thermal grill with alternating hot and cold bars, while digit 3 is placed on cardboard, the sensation of pain will also spread to the middle finger.
View details for DOI 10.1068/p7019
View details for Web of Science ID 000310184600012
View details for PubMedID 23155740
We showed a grapheme-color synesthete three different examples of stimuli in which the graphemes were 'hidden'--as in puzzle pictures--and became visible as letters only after prolonged viewing. Intriguingly the subject saw the appropriate colors accurately long before the graphemes became consciously visible--a novel form of blindsight.
View details for DOI 10.1068/p6861
View details for Web of Science ID 000292721500009
View details for PubMedID 21805923