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Dr. Yasser El-Sayed is a specialist in Maternal-Fetal Medicine and Obstetrics. His interests include maternal medical and surgical complications of pregnancy and prenatal diagnosis.
High Risk Obstetrics: preterm labor, preeclampsia, medical and surgical complications of pregnancy, prenatal diagnosis and therapy
Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Not Recruiting
Chorioamnionitis is an infection of the placenta and amniotic membranes (bag of waters) surrounding the baby inside of a pregnant woman prior to delivery. This infection is somewhat common and is routinely treated with antibiotics given to the mother both before and after the baby is born. Currently it is not known what is the best choice of antibiotics to treat this type of infection, but commonly used treatments include Unasyn (ampicillin/sulbactam) or ampicillin/gentamicin. We plan to compare these two different antibiotic regimens to see if one is better than the other at treating and preventing bad outcomes from chorioamnionitis in women and babies.
Stanford is currently not accepting patients for this trial. For more information, please contact Mara Greenberg, 4158672051.
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Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial Not Recruiting
Preterm delivery is the most common cause of infant morbidity and mortality in the United States. Some women have episodes of preterm labor during their pregnancy which can be temporarily stopped. These women, however, are at high risk for delivering before term. At this time, we do not have sufficient evidence to use any medication to help prevent these women from delivering early. Recently, preliminary studies have shown that progesterone may help prevent some women at high risk for preterm delivery from delivering early. Our study will investigate whether progesterone can help this specific group of women, women with arrested preterm labor, deliver healthy infants at term.
Stanford is currently not accepting patients for this trial. For more information, please contact Elizabeth S Langen, MD, .
Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial. Not Recruiting
Preterm birth is the leading cause of neonatal death and a significant cause of life long disability and health problems. It has been shown that the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm delivery in women with certain risk factors for preterm birth. We hope to learn whether this same medication can be used to prolong pregnancy in a group of patients in whom this medication has not been previously studied. Specifically, we hope to learn whether progesterone supplementation will delay delivery in women with pre-term, premature rupture of membranes (PPROM).
Stanford is currently not accepting patients for this trial. For more information, please contact Cynthia Willson, RN, 650-724-6372.
Fetal ST Segment and T Wave Analysis in Labor Recruiting
The purpose of this research is to test a new instrument, called a fetal STAN monitor, that may be used during labor to monitor the electrical activity of the baby's heart. This new instrument is designed to help the doctor determine how well the baby is doing during labor. It will be used along with the existing electronic fetal monitor used to measure the baby's heart rate and the mother's contractions during birth. The specific purpose of this research study is to see if this new instrument (fetal STAN monitor) will have an impact on newborn health.
Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis Not Recruiting
To compare once daily versus 8 hour dosing of gentamicin for the treatment of chorioamnionitis.
Stanford is currently not accepting patients for this trial. For more information, please contact Yasser El-Sayed, 6507233198.
An Observational Study of Hepatitis C Virus in Pregnancy Recruiting
This multi-center observational study examines risk factors for HCV transmission from mother to baby.
A Randomized Trial of Induction Versus Expectant Management Recruiting
A randomized clinical trial to assess whether elective induction of labor at 39 weeks of gestation compared with expectant management will improve outcomes.
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix Recruiting
This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.
Chronic Hypertension and Pregnancy (CHAP) Project Recruiting
The purpose of this study is to evaluate whether a blood pressure treatment strategy during pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults (<140/90 mmHg) compared ACOG- recommended standard during pregnancy (no treatment unless BP is severe) is effective and safe.
Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Recruiting
This is a randomized placebo controlled trial to evaluate whether antenatal corticosteroids can decrease the rate of neonatal respiratory support, thus decreasing the rate of NICU admissions and improving short-term outcomes in the late preterm infant. The use of antenatal corticosteroids has been shown to be beneficial in women at risk for preterm delivery prior to 34 weeks but has not been evaluated in those likely to deliver in the late preterm period
A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting
Cytomegalovirus (CMV) is a common virus that usually presents with few if any side effects. When first infected, some people may have symptoms similar to mononucleosis (i.e., fatigue, weakness, fever, swollen glands). Most people in the United States are infected during childhood or as adults if they work around children. Pregnant women, who have not been infected with CMV in the past and become infected during pregnancy (i.e. a primary infection), may cause their babies to get infected with CMV. Babies that are infected may develop permanent disabilities including hearing loss and a small portion will die from the infection. Currently it is not routine practice to screen pregnant women for CMV infection. Additionally, there is no agreement about how to evaluate and manage pregnant women infected with CMV for the first time. There is also no evidence that treatment is beneficial for the baby. The purpose of this research study is to determine whether treating pregnant women who have a primary CMV infection with CMV antibodies will reduce the number of babies infected with CMV.
Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate Not Recruiting
The purpose of this study is to determine the efficacy and safety of the addition of intravaginal isosorbide mononitrate to an established protocol of oral misoprostol for cervical ripening and labor induction.
Correlation of Continuous Glucose Monitoring and Glucose Tolerance Testing With Pregnancy Outcomes Not Recruiting
Diabetic pregnant patients are at risk for adverse pregnancy outcomes, including larger than expected fetuses and unplanned operative deliveries, due to elevated blood glucose levels. the one-hour glucola test is currently used to screen pregnant patients for gestational diabetes. This involves ingesting a 50-gram glucose load, followed by a blood test one hour later. We wish to compare 7-day continuous glucose monitoring to the one-hour glucola test, and determine which one correlates better with adverse pregnancy outcomes as well as which one more accurately identifies patients at risk for adverse pregnancy outcomes.
Stanford is currently not accepting patients for this trial. For more information, please contact Sung Joyce, 6508045956.
Early Screening and Treatment of Women With Prediabetes in Pregnancy Not Recruiting
The investigators hope to learn whether treatment with medical nutrition therapy (MNT) for pregnant women with prediabetes decreases the rate and severity of impaired glucose tolerance later in pregnancy and improves perinatal outcomes. Given the rising rates of obesity and diabetes in this country even among young women and the adverse affects of diabetes of pregnant women and their infants, the investigators feel that it is important to not only identify women at high risk for diabetes early in pregnancy but determine the appropriate management strategy
Stanford is currently not accepting patients for this trial. For more information, please contact Sarah S Osmundson, MD, 312-479-3130.
Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Not Recruiting
We hope to clarify how betamethasone affects glucose levels in the mother in the days after receiving the drug. This understanding will hopefully allow us to better anticipate the risk of maternal hyperglycemia and therefore establish more appropriate monitoring of maternal glucose to prevent maternal and neonatal complications of hyperglycemia.
Antibiotics for Postpartum Third and Fourth Degree Perineal Tear Repairs Not Recruiting
This study is undertaken to find out whether prophylactic antibiotics can decrease the infection rate in third and fourth degree perineal tear repairs done in the immediate postpartum period.
Nitroglycerin Versus Terbutaline for Intrapartum Fetal Resuscitation Not Recruiting
To compare nitroglycerin and terbutaline for intrapartum fetal heart rate resuscitation
Correlation Between Continuous Glucose Monitoring and Intermittent Glucose Monitoring Values and Pregnancy Outcomes Not Recruiting
We wish to find out if in non-diabetic pregnancies, as well as diabetic pregnancies, additional data obtained by Continuous Glucose Monitoring improves perinatal risk prediction.
Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial Not Recruiting
To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor
Magnesium Sulfate vs Placebo for Placental Abruption Not Recruiting
To evaluate the safety and efficacy of magnesium sulfate for preterm suspected abruption.
Stanford is currently not accepting patients for this trial. For more information, please contact Iris Colon, MD, (408) 855-5550.
Nifedipine vs Placebo for Maintenance Tocolysis of Preterm Labor. Not Recruiting
Comparing nifedipine to placebo for the maintenance tocolysis of preterm labor
